BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP3 matrix metallopeptidase 3
MT1X metallothionein 1X
ORM1 orosomucoid 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SELE selectin E
SERTAD2 SERTA domain containing 2
SFN stratifin
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
THBD thrombomodulin
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WISP2 WNT1 inducible signaling pathway protein 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
CCNA2 cyclin A2
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
DKK1 dickkopf WNT signaling pathway inhibitor 1
GSTP1 glutathione S-transferase pi 1
HOXA10 homeobox A10
MARCKSL1 MARCKS-like 1
NRIP1 nuclear receptor interacting protein 1
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
ZBTB18 zinc finger and BTB domain containing 18