BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANGPTL2 angiopoietin-like 2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C1ORF106 chromosome 1 open reading frame 106
CA2 carbonic anhydrase II
COCH cochlin
COL9A2 collagen, type IX, alpha 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGKV4-1 immunoglobulin kappa variable 4-1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LAPTM4B lysosomal protein transmembrane 4 beta
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE4A phosphodiesterase 4A, cAMP-specific
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRP1 arginine/serine-rich protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SPAG9 sperm associated antigen 9
SULF1 sulfatase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TIMP3 TIMP metallopeptidase inhibitor 3
TRIB1 tribbles pseudokinase 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AIM1 absent in melanoma 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGAP29 Rho GTPase activating protein 29
ARMT1 acidic residue methyltransferase 1
ATF1 activating transcription factor 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BEX1 brain expressed, X-linked 1
CCNA2 cyclin A2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHGB chromogranin B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
DCK deoxycytidine kinase
DHCR24 24-dehydrocholesterol reductase
GMDS GDP-mannose 4,6-dehydratase
GPX1 glutathione peroxidase 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HOXC6 homeobox C6
ITM2A integral membrane protein 2A
KRT7 keratin 7, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRFAP1L1 Morf4 family associated protein 1-like 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPY1R neuropeptide Y receptor Y1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRSS23 protease, serine, 23
PSIP1 PC4 and SFRS1 interacting protein 1
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
RAB11A RAB11A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RPL27A ribosomal protein L27a
RRP1B ribosomal RNA processing 1B
S100A11 S100 calcium binding protein A11
SELT selenoprotein T
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
TBC1D31 TBC1 domain family, member 31
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TRAM1 translocation associated membrane protein 1
TRD T cell receptor delta locus
TRIM22 tripartite motif containing 22
TSPAN13 tetraspanin 13
TSTA3 tissue specific transplantation antigen P35B
TXNDC9 thioredoxin domain containing 9
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VRK2 vaccinia related kinase 2