BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

239 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD11 ankyrin repeat domain 11
ANKRD12 ankyrin repeat domain 12
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COBL cordon-bleu WH2 repeat protein
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERO1L ERO1-like (S. cerevisiae)
FAM46A family with sequence similarity 46, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAB2 GRB2-associated binding protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6 interleukin 6
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM7A lysine (K)-specific demethylase 7A
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEF2A myocyte enhancer factor 2A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NLGN4X neuroligin 4, X-linked
NOTCH2NL notch 2 N-terminal like
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPL1 nucleoporin like 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK5 proprotein convertase subtilisin/kexin type 5
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPAG9 sperm associated antigen 9
STC1 stanniocalcin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TESK1 testis-specific kinase 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ACPP acid phosphatase, prostate
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AIM1 absent in melanoma 1
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BANK1 B-cell scaffold protein with ankyrin repeats 1
BEX1 brain expressed, X-linked 1
C4ORF27 chromosome 4 open reading frame 27
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CHMP6 charged multivesicular body protein 6
COA3 cytochrome c oxidase assembly factor 3
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLD dihydrolipoamide dehydrogenase
EDN1 endothelin 1
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FEN1 flap structure-specific endonuclease 1
FZD7 frizzled class receptor 7
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOPX HOP homeobox
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KLHL9 kelch-like family member 9
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MRPS12 mitochondrial ribosomal protein S12
MRPS16 mitochondrial ribosomal protein S16
MTCL1 microtubule crosslinking factor 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
NPY neuropeptide Y
NREP neuronal regeneration related protein
NXN nucleoredoxin
OLFM4 olfactomedin 4
PAIP1 poly(A) binding protein interacting protein 1
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SELT selenoprotein T
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTSSA serine palmitoyltransferase, small subunit A
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRAPPC4 trafficking protein particle complex 4
TYRP1 tyrosinase-related protein 1
UMPS uridine monophosphate synthetase
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
ZBED5 zinc finger, BED-type containing 5
ZBTB18 zinc finger and BTB domain containing 18