BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CERS6 ceramide synthase 6
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
ERO1L ERO1-like (S. cerevisiae)
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GAB2 GRB2-associated binding protein 2
GLUL glutamate-ammonia ligase
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
INSIG1 insulin induced gene 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFSD10 major facilitator superfamily domain containing 10
MYO1B myosin IB
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PER1 period circadian clock 1
PGK1 phosphoglycerate kinase 1
PLEC plectin
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RHOB ras homolog family member B
S100A7 S100 calcium binding protein A7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
STC1 stanniocalcin 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
ANXA4 annexin A4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBR3 carbonyl reductase 3
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEP68 centrosomal protein 68kDa
DHRS11 dehydrogenase/reductase (SDR family) member 11
FANCF Fanconi anemia, complementation group F
FBLN1 fibulin 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPRC5B G protein-coupled receptor, class C, group 5, member B
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HOXA5 homeobox A5
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JCHAIN joining chain of multimeric IgA and IgM
KIAA0391 KIAA0391
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LEFTY1 left-right determination factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LRRC17 leucine rich repeat containing 17
MAP2K6 mitogen-activated protein kinase kinase 6
MID1 midline 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDN necdin, melanoma antigen (MAGE) family member
NLRP2 NLR family, pyrin domain containing 2
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLCL2 phospholipase C-like 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLN phospholamban
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PSIP1 PC4 and SFRS1 interacting protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SPTSSA serine palmitoyltransferase, small subunit A
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRD T cell receptor delta locus
TXNDC9 thioredoxin domain containing 9
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UMPS uridine monophosphate synthetase
WDR61 WD repeat domain 61