BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM19 ADAM metallopeptidase domain 19
ANXA6 annexin A6
BCHE butyrylcholinesterase
BMP4 bone morphogenetic protein 4
CCL2 chemokine (C-C motif) ligand 2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTTN cortactin
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GFPT2 glutamine-fructose-6-phosphate transaminase 2
IER3 immediate early response 3
IL7R interleukin 7 receptor
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RTN3 reticulon 3
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOWAHC sosondowah ankyrin repeat domain family member C
TSPAN5 tetraspanin 5
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BAMBI BMP and activin membrane-bound inhibitor
CALR calreticulin
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
COMMD3 COMM domain containing 3
CXCL14 chemokine (C-X-C motif) ligand 14
EAPP E2F-associated phosphoprotein
FBXL12 F-box and leucine-rich repeat protein 12
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
HIST1H2AC histone cluster 1, H2ac
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KRT10 keratin 10, type I
LPL lipoprotein lipase
LXN latexin
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MPC2 mitochondrial pyruvate carrier 2
MSRB2 methionine sulfoxide reductase B2
MTA1 metastasis associated 1
NPY1R neuropeptide Y receptor Y1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLEK pleckstrin
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RBP4 retinol binding protein 4, plasma
RGS1 regulator of G-protein signaling 1
SAR1B secretion associated, Ras related GTPase 1B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMC1A structural maintenance of chromosomes 1A
SNX10 sorting nexin 10
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TMEM47 transmembrane protein 47
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28