BRD-K57480017_4-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid WFM1.17C_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K57480017_4-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid WFM1.17C_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF5B eukaryotic translation initiation factor 5B
FGFR4 fibroblast growth factor receptor 4
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HES1 hes family bHLH transcription factor 1
IGLV2-23 immunoglobulin lambda variable 2-23
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LMO4 LIM domain only 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
RAD51C RAD51 paralog C
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SLC38A1 solute carrier family 38, member 1
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TOB1 transducer of ERBB2, 1
TSPAN5 tetraspanin 5
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ACADVL acyl-CoA dehydrogenase, very long chain
AGTR1 angiotensin II receptor, type 1
AKR1C2 aldo-keto reductase family 1, member C2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASMTL acetylserotonin O-methyltransferase-like
BCL6 B-cell CLL/lymphoma 6
C2CD2 C2 calcium-dependent domain containing 2
CCNA1 cyclin A1
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHGB chromogranin B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EDNRB endothelin receptor type B
ESR1 estrogen receptor 1
FAM46A family with sequence similarity 46, member A
FBXL12 F-box and leucine-rich repeat protein 12
GRIA2 glutamate receptor, ionotropic, AMPA 2
INSM1 insulinoma-associated 1
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MCF2L MCF.2 cell line derived transforming sequence-like
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MX2 MX dynamin-like GTPase 2
NOTCH3 notch 3
NOV nephroblastoma overexpressed
PCP4 Purkinje cell protein 4
PDGFD platelet derived growth factor D
RET ret proto-oncogene
RTN2 reticulon 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TCTA T-cell leukemia translocation altered
TNNC1 troponin C type 1 (slow)
TNS3 tensin 3
TRD T cell receptor delta locus
VEGFA vascular endothelial growth factor A
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91