BRD-K57353465_N-benzyl-2-(indolin-1-yl)quinazolin-4-amine KUC106468N_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K57353465_N-benzyl-2-(indolin-1-yl)quinazolin-4-amine KUC106468N_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP13 A kinase (PRKA) anchor protein 13
ANPEP alanyl (membrane) aminopeptidase
APOA2 apolipoprotein A-II
APOB apolipoprotein B
ASPN asporin
BEX1 brain expressed, X-linked 1
BGN biglycan
CALR calreticulin
CD99 CD99 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CLEC11A C-type lectin domain family 11, member A
COL15A1 collagen, type XV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRISP3 cysteine-rich secretory protein 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FAM117A family with sequence similarity 117, member A
HBE1 hemoglobin, epsilon 1
HHEX hematopoietically expressed homeobox
HIP1R huntingtin interacting protein 1 related
HIST1H2BG histone cluster 1, H2bg
HP haptoglobin
HSPG2 heparan sulfate proteoglycan 2
KDM5D lysine (K)-specific demethylase 5D
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
LMNA lamin A/C
LOC100286895 cell division cycle 27 homolog pseudogene
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MEIS1 Meis homeobox 1
MMP11 matrix metallopeptidase 11
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSX1 msh homeobox 1
MUC16 mucin 16, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
NFE2 nuclear factor, erythroid 2
NOTCH1 notch 1
NOTCH3 notch 3
PDIA3 protein disulfide isomerase family A, member 3
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PLK2 polo-like kinase 2
PODXL podocalyxin-like
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB25 RAB25, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SALL1 spalt-like transcription factor 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPATS2L spermatogenesis associated, serine-rich 2-like
SPON2 spondin 2, extracellular matrix protein
STC1 stanniocalcin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFA transforming growth factor, alpha
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
UBE2A ubiquitin-conjugating enzyme E2A
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL1 ADP-ribosylation factor-like 1
ARMCX1 armadillo repeat containing, X-linked 1
ARMT1 acidic residue methyltransferase 1
ATF1 activating transcription factor 1
C1QA complement component 1, q subcomponent, A chain
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CAV2 caveolin 2
CCL19 chemokine (C-C motif) ligand 19
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDK4 cyclin-dependent kinase 4
CFD complement factor D (adipsin)
CFH complement factor H
CHMP4A charged multivesicular body protein 4A
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CREBL2 cAMP responsive element binding protein-like 2
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CTSS cathepsin S
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ERLIN2 ER lipid raft associated 2
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GGT1 gamma-glutamyltransferase 1
GMNN geminin, DNA replication inhibitor
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GTPBP8 GTP-binding protein 8 (putative)
HDGFRP3 hepatoma-derived growth factor, related protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KIF14 kinesin family member 14
KLK2 kallikrein-related peptidase 2
KRT14 keratin 14, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LRRN3 leucine rich repeat neuronal 3
LUM lumican
LYPLA1 lysophospholipase I
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MT1E metallothionein 1E
MT1X metallothionein 1X
MYO5C myosin VC
NDNF neuron-derived neurotrophic factor
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
NMU neuromedin U
NOV nephroblastoma overexpressed
NRIP1 nuclear receptor interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDHX pyruvate dehydrogenase complex, component X
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
REEP5 receptor accessory protein 5
S100A13 S100 calcium binding protein A13
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGCE sarcoglycan, epsilon
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC38A1 solute carrier family 38, member 1
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF11 serine/arginine-rich splicing factor 11
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TMEM50B transmembrane protein 50B
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TSFM Ts translation elongation factor, mitochondrial
TSNAX translin-associated factor X
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TUBA4A tubulin, alpha 4a
TXNDC9 thioredoxin domain containing 9
UFM1 ubiquitin-fold modifier 1
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WRB tryptophan rich basic protein
XPO7 exportin 7
ZFAND1 zinc finger, AN1-type domain 1