BRD-K57353465_N-benzyl-2-(indolin-1-yl)quinazolin-4-amine KUC106468N_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K57353465_N-benzyl-2-(indolin-1-yl)quinazolin-4-amine KUC106468N_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
AEBP1 AE binding protein 1
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CD52 CD52 molecule
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
DCN decorin
DENND1B DENN/MADD domain containing 1B
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FAP fibroblast activation protein, alpha
FILIP1L filamin A interacting protein 1-like
FKBP11 FK506 binding protein 11, 19 kDa
FST follistatin
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HTRA1 HtrA serine peptidase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
JAG1 jagged 1
LINC00341 long intergenic non-protein coding RNA 341
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP9 matrix metallopeptidase 9
MOSPD1 motile sperm domain containing 1
MYO1D myosin ID
MZB1 marginal zone B and B1 cell-specific protein
NEB nebulin
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PBX1 pre-B-cell leukemia homeobox 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPN podoplanin
PEG10 paternally expressed 10
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMM2 phosphomannomutase 2
POU2AF1 POU class 2 associating factor 1
PRKX protein kinase, X-linked
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPRE protein tyrosine phosphatase, receptor type, E
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SFRP4 secreted frizzled-related protein 4
SHB Src homology 2 domain containing adaptor protein B
SIRPA signal-regulatory protein alpha
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TLK2 tousled-like kinase 2
TMEM176B transmembrane protein 176B
TRIM2 tripartite motif containing 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
APOD apolipoprotein D
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CD151 CD151 molecule (Raph blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CRYAB crystallin, alpha B
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM171A1 family with sequence similarity 171, member A1
FOLR1 folate receptor 1 (adult)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IFI6 interferon, alpha-inducible protein 6
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF5C kinesin family member 5C
KRT10 keratin 10, type I
LDHB lactate dehydrogenase B
LIMCH1 LIM and calponin homology domains 1
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NFIB nuclear factor I/B
PIP prolactin-induced protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
QDPR quinoid dihydropteridine reductase
RNH1 ribonuclease/angiogenin inhibitor 1
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SORD sorbitol dehydrogenase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8