BRD-K57282030_JW-7-24-1_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K57282030_JW-7-24-1_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ASS1 argininosuccinate synthase 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP22 dual specificity phosphatase 22
EBP emopamil binding protein (sterol isomerase)
ETV1 ets variant 1
EZR ezrin
FADS1 fatty acid desaturase 1
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FN1 fibronectin 1
FOXO4 forkhead box O4
FST follistatin
GAS6 growth arrest-specific 6
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LINC00342 long intergenic non-protein coding RNA 342
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LXN latexin
MBNL2 muscleblind-like splicing regulator 2
MLPH melanophilin
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
ORAI3 ORAI calcium release-activated calcium modulator 3
PAWR PRKC, apoptosis, WT1, regulator
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RALGDS ral guanine nucleotide dissociation stimulator
RTN2 reticulon 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFTPC surfactant protein C
SFTPD surfactant protein D
SGCE sarcoglycan, epsilon
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SREBF2 sterol regulatory element binding transcription factor 2
SRPX sushi-repeat containing protein, X-linked
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TPP1 tripeptidyl peptidase I
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ARG2 arginase 2
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BOP1 block of proliferation 1
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLM1 golgi membrane protein 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H4C histone cluster 1, H4c
HSPA14 heat shock 70kDa protein 14
ICMT isoprenylcysteine carboxyl methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP5 insulin-like growth factor binding protein 5
KIF5B kinesin family member 5B
KRT14 keratin 14, type I
LEF1 lymphoid enhancer-binding factor 1
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NELL2 NEL-like 2 (chicken)
NPY neuropeptide Y
OIP5 Opa interacting protein 5
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PBK PDZ binding kinase
PDE10A phosphodiesterase 10A
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRKCH protein kinase C, eta
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
SMC2 structural maintenance of chromosomes 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2S ubiquitin-conjugating enzyme E2S
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein