BRD-K57282030_JW-7-24-1_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K57282030_JW-7-24-1_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP9 aquaporin 9
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD38 CD38 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
EPCAM epithelial cell adhesion molecule
EPS8 epidermal growth factor receptor pathway substrate 8
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GSAP gamma-secretase activating protein
GTPBP8 GTP-binding protein 8 (putative)
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
KRT15 keratin 15, type I
KYNU kynureninase
LDLR low density lipoprotein receptor
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP9 matrix metallopeptidase 9
NPC2 Niemann-Pick disease, type C2
NRIP1 nuclear receptor interacting protein 1
PLAU plasminogen activator, urokinase
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SPARCL1 SPARC-like 1 (hevin)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TSC22D3 TSC22 domain family, member 3
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
C2CD2 C2 calcium-dependent domain containing 2
C6ORF62 chromosome 6 open reading frame 62
CCR7 chemokine (C-C motif) receptor 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
DEGS1 delta(4)-desaturase, sphingolipid 1
EPHA3 EPH receptor A3
GATA2 GATA binding protein 2
GHR growth hormone receptor
HOXB6 homeobox B6
HOXC6 homeobox C6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KLF4 Kruppel-like factor 4 (gut)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRN3 leucine rich repeat neuronal 3
MAGEA1 melanoma antigen family A1
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN2 reticulon 2
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SRGN serglycin
TNNC1 troponin C type 1 (slow)
TPM1 tropomyosin 1 (alpha)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
ZEB1 zinc finger E-box binding homeobox 1