BRD-K57282030_JW-7-24-1_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K57282030_JW-7-24-1_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
C10ORF10 chromosome 10 open reading frame 10
C11ORF80 chromosome 11 open reading frame 80
C14ORF132 chromosome 14 open reading frame 132
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHGB chromogranin B
COLEC12 collectin sub-family member 12
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DUSP4 dual specificity phosphatase 4
EFNB2 ephrin-B2
EZR ezrin
FAXDC2 fatty acid hydroxylase domain containing 2
FHL1 four and a half LIM domains 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GPX3 glutathione peroxidase 3
GSE1 Gse1 coiled-coil protein
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IDS iduronate 2-sulfatase
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
ITGB4 integrin, beta 4
KDM5B lysine (K)-specific demethylase 5B
KYNU kynureninase
LAMA3 laminin, alpha 3
LAT2 linker for activation of T cells family, member 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEF2C myocyte enhancer factor 2C
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5E 5'-nucleotidase, ecto (CD73)
PECAM1 platelet/endothelial cell adhesion molecule 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG10 paternally expressed 10
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
RABAC1 Rab acceptor 1 (prenylated)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELN reelin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS2 son of sevenless homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TNIP1 TNFAIP3 interacting protein 1
TNNT1 troponin T type 1 (skeletal, slow)
VEGFC vascular endothelial growth factor C
VNN1 vanin 1
WNK1 WNK lysine deficient protein kinase 1
ZC2HC1A zinc finger, C2HC-type containing 1A

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATG3 autophagy related 3
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNC cyclin C
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPN centromere protein N
CKS2 CDC28 protein kinase regulatory subunit 2
COL3A1 collagen, type III, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FGFR3 fibroblast growth factor receptor 3
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GGCT gamma-glutamylcyclotransferase
HAT1 histone acetyltransferase 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MLEC malectin
MOCS2 molybdenum cofactor synthesis 2
MRPS30 mitochondrial ribosomal protein S30
MUC4 mucin 4, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEK2 NIMA-related kinase 2
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSAT1 phosphoserine aminotransferase 1
PTGES3 prostaglandin E synthase 3 (cytosolic)
QDPR quinoid dihydropteridine reductase
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SORD sorbitol dehydrogenase
TPD52 tumor protein D52
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S