BRD-K57282030_JW-7-24-1_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K57282030_JW-7-24-1_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AIM2 absent in melanoma 2
ANKRD36B ankyrin repeat domain 36B
ASPN asporin
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
FADS2 fatty acid desaturase 2
FAP fibroblast activation protein, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXD1 forkhead box D1
FXYD2 FXYD domain containing ion transport regulator 2
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GRB14 growth factor receptor-bound protein 14
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
HP haptoglobin
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP1 insulin-like growth factor binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAG1 jagged 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LETMD1 LETM1 domain containing 1
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MSMO1 methylsterol monooxygenase 1
MYO6 myosin VI
NINL ninein-like
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
PCDH9 protocadherin 9
PEG3 paternally expressed 3
RAB31 RAB31, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS17 regulator of G-protein signaling 17
RRAGC Ras-related GTP binding C
SC5D sterol-C5-desaturase
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPON2 spondin 2, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TCF25 transcription factor 25 (basic helix-loop-helix)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TMEM135 transmembrane protein 135
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TTC3 tetratricopeptide repeat domain 3
VCAN versican
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CENPU centromere protein U
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP2 epithelial membrane protein 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FOXF1 forkhead box F1
GALE UDP-galactose-4-epimerase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLC glutamate-cysteine ligase, catalytic subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IGKC immunoglobulin kappa constant
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
OLFM1 olfactomedin 1
PCNA proliferating cell nuclear antigen
PEX11A peroxisomal biogenesis factor 11 alpha
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RFC2 replication factor C (activator 1) 2, 40kDa
RPA3 replication protein A3, 14kDa
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
STXBP6 syntaxin binding protein 6 (amisyn)
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
WARS tryptophanyl-tRNA synthetase
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein