BRD-K57282030_JW-7-24-1_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K57282030_JW-7-24-1_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
BID BH3 interacting domain death agonist
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CAV2 caveolin 2
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COLEC12 collectin sub-family member 12
CREB3L2 cAMP responsive element binding protein 3-like 2
CST3 cystatin C
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FLRT2 fibronectin leucine rich transmembrane protein 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MSLN mesothelin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYOF myoferlin
NID1 nidogen 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5E 5'-nucleotidase, ecto (CD73)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR3 phospholipid scramblase 3
PLSCR4 phospholipid scramblase 4
PSD3 pleckstrin and Sec7 domain containing 3
RFTN1 raftlin, lipid raft linker 1
RIN2 Ras and Rab interactor 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYT17 synaptotagmin XVII
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRIM2 tripartite motif containing 2
UGDH UDP-glucose 6-dehydrogenase
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
C1ORF106 chromosome 1 open reading frame 106
CALML3 calmodulin-like 3
CCL19 chemokine (C-C motif) ligand 19
CD69 CD69 molecule
CDC42 cell division cycle 42
CKLF chemokine-like factor
CSRP2 cysteine and glycine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
HSPB8 heat shock 22kDa protein 8
IGKC immunoglobulin kappa constant
MAPK13 mitogen-activated protein kinase 13
MBP myelin basic protein
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYLK myosin light chain kinase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PITX1 paired-like homeodomain 1
PLAC8 placenta-specific 8
PRDX2 peroxiredoxin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS1 regulator of G-protein signaling 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
TARP TCR gamma alternate reading frame protein
TARS threonyl-tRNA synthetase
TNC tenascin C
TYRP1 tyrosinase-related protein 1
VCAM1 vascular cell adhesion molecule 1