BRD-K57080016_selumetinib_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K57080016_selumetinib_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADA adenosine deaminase
AKR1C2 aldo-keto reductase family 1, member C2
BAMBI BMP and activin membrane-bound inhibitor
C10ORF10 chromosome 10 open reading frame 10
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CRABP2 cellular retinoic acid binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DOK5 docking protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
FGFR3 fibroblast growth factor receptor 3
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GRAMD3 GRAM domain containing 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H1C histone cluster 1, H1c
HOPX HOP homeobox
HOXA5 homeobox A5
HOXC6 homeobox C6
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ISG15 ISG15 ubiquitin-like modifier
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LTBP2 latent transforming growth factor beta binding protein 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PBX1 pre-B-cell leukemia homeobox 1
PFN2 profilin 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
SKAP2 src kinase associated phosphoprotein 2
SQLE squalene epoxidase
STOM stomatin
TLE4 transducin-like enhancer of split 4
TPBG trophoblast glycoprotein

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIM1 absent in melanoma 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCND1 cyclin D1
CD24 CD24 molecule
CHGB chromogranin B
COG5 component of oligomeric golgi complex 5
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EDNRB endothelin receptor type B
EGR1 early growth response 1
EGR3 early growth response 3
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
IER3 immediate early response 3
ITGA6 integrin, alpha 6
JAG1 jagged 1
JUN jun proto-oncogene
KYNU kynureninase
LEFTY1 left-right determination factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MFSD12 major facilitator superfamily domain containing 12
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NEFL neurofilament, light polypeptide
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PMP22 peripheral myelin protein 22
QPCT glutaminyl-peptide cyclotransferase
SATB2 SATB homeobox 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
SVIL supervillin
TCL1A T-cell leukemia/lymphoma 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb