BRD-K57080016_selumetinib_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K57080016_selumetinib_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ANXA4 annexin A4
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
BEX4 brain expressed, X-linked 4
BST2 bone marrow stromal cell antigen 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
COL5A1 collagen, type V, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYB5A cytochrome b5 type A (microsomal)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSTN destrin (actin depolymerizing factor)
EFNA1 ephrin-A1
FAM117A family with sequence similarity 117, member A
FILIP1L filamin A interacting protein 1-like
FLNB filamin B, beta
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
FYN FYN proto-oncogene, Src family tyrosine kinase
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA6 GATA binding protein 6
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPG2 heparan sulfate proteoglycan 2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNGR1 interferon gamma receptor 1
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAGEA3 melanoma antigen family A3
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MUC1 mucin 1, cell surface associated
MX2 MX dynamin-like GTPase 2
MYL9 myosin, light chain 9, regulatory
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OSBPL9 oxysterol binding protein-like 9
OSR2 odd-skipped related transciption factor 2
PDLIM1 PDZ and LIM domain 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PRKCI protein kinase C, iota
PROS1 protein S (alpha)
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS5 regulator of G-protein signaling 5
RNF103 ring finger protein 103
SC5D sterol-C5-desaturase
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
THBS2 thrombospondin 2
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ADRB2 adrenoceptor beta 2, surface
ANO1 anoctamin 1, calcium activated chloride channel
ASPH aspartate beta-hydroxylase
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CDCP1 CUB domain containing protein 1
CENPU centromere protein U
CLC Charcot-Leyden crystal galectin
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FZD1 frizzled class receptor 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCLC glutamate-cysteine ligase, catalytic subunit
GPM6B glycoprotein M6B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA1 high mobility group AT-hook 1
HMGB2 high mobility group box 2
IDO1 indoleamine 2,3-dioxygenase 1
ITGA6 integrin, alpha 6
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0226L KIAA0226-like
LTF lactotransferrin
MCM3 minichromosome maintenance complex component 3
MGLL monoglyceride lipase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO10 myosin X
NDC80 NDC80 kinetochore complex component
NT5E 5'-nucleotidase, ecto (CD73)
ORC1 origin recognition complex, subunit 1
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMP22 peripheral myelin protein 22
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RRM2 ribonucleotide reductase M2
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)