BRD-K57080016_selumetinib_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K57080016_selumetinib_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
C14ORF132 chromosome 14 open reading frame 132
CLU clusterin
CRYAB crystallin, alpha B
CXCL5 chemokine (C-X-C motif) ligand 5
EDNRB endothelin receptor type B
EFHD1 EF-hand domain family, member D1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GATA6 GATA binding protein 6
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTM3 glutathione S-transferase mu 3 (brain)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IQGAP2 IQ motif containing GTPase activating protein 2
KAT6B K(lysine) acetyltransferase 6B
KRT4 keratin 4, type II
LTBP1 latent transforming growth factor beta binding protein 1
MAMLD1 mastermind-like domain containing 1
MATN2 matrilin 2
MYH11 myosin, heavy chain 11, smooth muscle
NEBL nebulette
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RELN reelin
RGS2 regulator of G-protein signaling 2
RRAGD Ras-related GTP binding D
SHCBP1 SHC SH2-domain binding protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
TAGLN transgelin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDCP1 CUB domain containing protein 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EPHA2 EPH receptor A2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
EXOSC4 exosome component 4
FAM60A family with sequence similarity 60, member A
FAP fibroblast activation protein, alpha
FOSL1 FOS-like antigen 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
KDM5D lysine (K)-specific demethylase 5D
LDLR low density lipoprotein receptor
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEB nebulin
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAUR plasminogen activator, urokinase receptor
POPDC3 popeye domain containing 3
RAB31 RAB31, member RAS oncogene family
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SH2B3 SH2B adaptor protein 3
SIK1 salt-inducible kinase 1
SMAGP small cell adhesion glycoprotein
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1