BRD-K57080016_selumetinib_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

271 genes differentially expressed following the BRD-K57080016_selumetinib_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AFF1 AF4/FMR2 family, member 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BEX1 brain expressed, X-linked 1
BTN3A2 butyrophilin, subfamily 3, member A2
C1ORF106 chromosome 1 open reading frame 106
C1RL complement component 1, r subcomponent-like
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CHPT1 choline phosphotransferase 1
CTSA cathepsin A
CTSB cathepsin B
CTSS cathepsin S
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP22 dual specificity phosphatase 22
EFNA1 ephrin-A1
ELF1 E74-like factor 1 (ets domain transcription factor)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERGIC3 ERGIC and golgi 3
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAP GABA(A) receptor-associated protein
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GRN granulin
GSN gelsolin
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IRS2 insulin receptor substrate 2
ISCU iron-sulfur cluster assembly enzyme
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LCN2 lipocalin 2
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
METTL7A methyltransferase like 7A
MGST3 microsomal glutathione S-transferase 3
MUC13 mucin 13, cell surface associated
MVP major vault protein
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGDHL oxoglutarate dehydrogenase-like
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFC platelet derived growth factor C
PHF1 PHD finger protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PINK1 PTEN induced putative kinase 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKCD protein kinase C, delta
PRSS8 protease, serine, 8
PSCA prostate stem cell antigen
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
QPRT quinolinate phosphoribosyltransferase
R3HDM2 R3H domain containing 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1CC1 RB1-inducible coiled-coil 1
REG1A regenerating islet-derived 1 alpha
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEPHS2 selenophosphate synthetase 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SI sucrase-isomaltase (alpha-glucosidase)
SIDT2 SID1 transmembrane family, member 2
SLC22A18 solute carrier family 22, member 18
SLC35E2B solute carrier family 35, member E2B
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYT17 synaptotagmin XVII
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
TSPAN6 tetraspanin 6
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VNN1 vanin 1
WBP1L WW domain binding protein 1-like
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WWOX WW domain containing oxidoreductase
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM9 ADAM metallopeptidase domain 9
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK4 adenylate kinase 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CCNF cyclin F
CD320 CD320 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDT1 chromatin licensing and DNA replication factor 1
CEMIP cell migration inducing protein, hyaluronan binding
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CPE carboxypeptidase E
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLS glutaminase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNLY granulysin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
H2AFX H2A histone family, member X
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KIAA0226L KIAA0226-like
LBR lamin B receptor
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPS12 mitochondrial ribosomal protein S12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PRC1 protein regulator of cytokinesis 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51 RAD51 recombinase
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SQLE squalene epoxidase
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein