BRD-K57080016_selumetinib_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

377 genes differentially expressed following the BRD-K57080016_selumetinib_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
ANXA9 annexin A9
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BBS1 Bardet-Biedl syndrome 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CAPN3 calpain 3, (p94)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CELF2 CUGBP, Elav-like family member 2
CES2 carboxylesterase 2
CFB complement factor B
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL14A1 collagen, type XIV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
CPQ carboxypeptidase Q
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DES desmin
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FDXR ferredoxin reductase
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HMGN3 high mobility group nucleosomal binding domain 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUP junction plakoglobin
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
LIMK2 LIM domain kinase 2
LMBRD1 LMBR1 domain containing 1
LTBP3 latent transforming growth factor beta binding protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
MSRB2 methionine sulfoxide reductase B2
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NCAM1 neural cell adhesion molecule 1
NCK2 NCK adaptor protein 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NPEPL1 aminopeptidase-like 1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OLFM4 olfactomedin 4
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL9 oxysterol binding protein-like 9
OSR2 odd-skipped related transciption factor 2
PBLD phenazine biosynthesis-like protein domain containing
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PFKL phosphofructokinase, liver
PFN2 profilin 2
PHYH phytanoyl-CoA 2-hydroxylase
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLN phospholamban
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2A phosphatidic acid phosphatase type 2A
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
PROS1 protein S (alpha)
PRUNE2 prune homolog 2 (Drosophila)
PYCARD PYD and CARD domain containing
PYGL phosphorylase, glycogen, liver
RABAC1 Rab acceptor 1 (prenylated)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBKS ribokinase
REEP1 receptor accessory protein 1
RPL31 ribosomal protein L31
RPS27L ribosomal protein S27-like
SCPEP1 serine carboxypeptidase 1
SCRG1 stimulator of chondrogenesis 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SIDT2 SID1 transmembrane family, member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORBS2 sorbin and SH3 domain containing 2
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TAGLN transgelin
TM7SF2 transmembrane 7 superfamily member 2
TMEM135 transmembrane protein 135
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TPPP3 tubulin polymerization-promoting protein family member 3
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAV3 vav 3 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANO1 anoctamin 1, calcium activated chloride channel
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
DBF4 DBF4 zinc finger
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DOCK4 dedicator of cytokinesis 4
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EIF4E eukaryotic translation initiation factor 4E
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV4 ets variant 4
ETV5 ets variant 5
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTPBP4 GTP binding protein 4
GTSE1 G-2 and S-phase expressed 1
H2AFZ H2A histone family, member Z
HBEGF heparin-binding EGF-like growth factor
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH2 mutS homolog 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NLRP2 NLR family, pyrin domain containing 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
NUP205 nucleoporin 205kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PRPF4 pre-mRNA processing factor 4
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
SEH1L SEH1-like (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SH2B3 SH2B adaptor protein 3
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TESC tescalcin
TFPI2 tissue factor pathway inhibitor 2
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMPO thymopoietin
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN5 tetraspanin 5
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UBE2C ubiquitin-conjugating enzyme E2C
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1
WWC1 WW and C2 domain containing 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZWINT ZW10 interacting kinetochore protein