BRD-K57080016_-666_SKMEL28_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-K57080016_-666_SKMEL28_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACD adrenocortical dysplasia homolog (mouse)
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CES2 carboxylesterase 2
CLC Charcot-Leyden crystal galectin
CLCA1 chloride channel accessory 1
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DOK5 docking protein 5
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
GAS6 growth arrest-specific 6
GPX2 glutathione peroxidase 2
GSE1 Gse1 coiled-coil protein
IGFBP5 insulin-like growth factor binding protein 5
ITM2C integral membrane protein 2C
KRT15 keratin 15, type I
LAMP3 lysosomal-associated membrane protein 3
LGALS4 lectin, galactoside-binding, soluble, 4
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MFAP5 microfibrillar associated protein 5
MPC2 mitochondrial pyruvate carrier 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC13 mucin 13, cell surface associated
MXRA5 matrix-remodelling associated 5
MYO1D myosin ID
NCAM1 neural cell adhesion molecule 1
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PPAP2A phosphatidic acid phosphatase type 2A
PTGIS prostaglandin I2 (prostacyclin) synthase
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
SDC1 syndecan 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SULF1 sulfatase 1
SYNPO synaptopodin
TF transferrin
TFF1 trefoil factor 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UBQLN2 ubiquilin 2
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
C3ORF52 chromosome 3 open reading frame 52
C8ORF4 chromosome 8 open reading frame 4
CAPN3 calpain 3, (p94)
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND1 cyclin D1
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHSY1 chondroitin sulfate synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EFHD2 EF-hand domain family, member D2
EGR1 early growth response 1
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EXOSC4 exosome component 4
FAM3C family with sequence similarity 3, member C
FCMR Fc fragment of IgM receptor
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD5 potassium channel tetramerization domain containing 5
LAMC2 laminin, gamma 2
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
LTF lactotransferrin
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NDP Norrie disease (pseudoglioma)
NOSIP nitric oxide synthase interacting protein
NOTCH2 notch 2
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKCH protein kinase C, eta
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RGS4 regulator of G-protein signaling 4
RRP1B ribosomal RNA processing 1B
SATB1 SATB homeobox 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMTN smoothelin
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STK32B serine/threonine kinase 32B
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TEX10 testis expressed 10
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
USP6NL USP6 N-terminal like
WWTR1 WW domain containing transcription regulator 1