BRD-K57080016_-666_SKM1_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-K57080016_-666_SKM1_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACADVL acyl-CoA dehydrogenase, very long chain
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APLP2 amyloid beta (A4) precursor-like protein 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CHN2 chimerin 2
CLIC4 chloride intracellular channel 4
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTIP cytohesin 1 interacting protein
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DMXL1 Dmx-like 1
DUSP1 dual specificity phosphatase 1
DZIP3 DAZ interacting zinc finger protein 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FHL1 four and a half LIM domains 1
FIG4 FIG4 phosphoinositide 5-phosphatase
FOXN3 forkhead box N3
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
GSDMB gasdermin B
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HDAC6 histone deacetylase 6
HECA headcase homolog (Drosophila)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
IDO1 indoleamine 2,3-dioxygenase 1
ITM2C integral membrane protein 2C
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MDFIC MyoD family inhibitor domain containing
MICALL1 MICAL-like 1
MYO1D myosin ID
MYOF myoferlin
NMRK1 nicotinamide riboside kinase 1
NPR3 natriuretic peptide receptor 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCCA propionyl CoA carboxylase, alpha polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNRC1 proline-rich nuclear receptor coactivator 1
PSAP prosaposin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBPMS RNA binding protein with multiple splicing
RGS1 regulator of G-protein signaling 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RYBP RING1 and YY1 binding protein
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOCS2 suppressor of cytokine signaling 2
STC2 stanniocalcin 2
SYT1 synaptotagmin I
TCEA1 transcription elongation factor A (SII), 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase
WDR7 WD repeat domain 7
YPEL5 yippee-like 5 (Drosophila)
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BAG1 BCL2-associated athanogene
BYSL bystin-like
C3 complement component 3
CA1 carbonic anhydrase I
CALD1 caldesmon 1
CCDC85B coiled-coil domain containing 85B
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND3 cyclin D3
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHSY1 chondroitin sulfate synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DPH2 DPH2 homolog (S. cerevisiae)
DTNA dystrobrevin, alpha
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EIF3J eukaryotic translation initiation factor 3, subunit J
EMP1 epithelial membrane protein 1
EXOSC4 exosome component 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM98A family with sequence similarity 98, member A
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FJX1 four jointed box 1 (Drosophila)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTPBP4 GTP binding protein 4
HBD hemoglobin, delta
HBE1 hemoglobin, epsilon 1
HHEX hematopoietically expressed homeobox
HN1L hematological and neurological expressed 1-like
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IFI44L interferon-induced protein 44-like
IFRD2 interferon-related developmental regulator 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
LAPTM5 lysosomal protein transmembrane 5
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
METRN meteorin, glial cell differentiation regulator
MFSD12 major facilitator superfamily domain containing 12
MMD monocyte to macrophage differentiation-associated
MRPL17 mitochondrial ribosomal protein L17
MRPS12 mitochondrial ribosomal protein S12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MT1X metallothionein 1X
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAMPT nicotinamide phosphoribosyltransferase
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NR2F6 nuclear receptor subfamily 2, group F, member 6
ORM1 orosomucoid 1
PA2G4 proliferation-associated 2G4, 38kDa
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRR7 proline rich 7 (synaptic)
PRSS21 protease, serine, 21 (testisin)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTRH2 peptidyl-tRNA hydrolase 2
PUS7 pseudouridylate synthase 7 (putative)
RFTN1 raftlin, lipid raft linker 1
RHOBTB3 Rho-related BTB domain containing 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
TAGLN2 transgelin 2
TCL1A T-cell leukemia/lymphoma 1A
TESC tescalcin
TFB2M transcription factor B2, mitochondrial
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN1 tetraspanin 1
TTLL12 tubulin tyrosine ligase-like family member 12
TUBA4A tubulin, alpha 4a
TXNDC9 thioredoxin domain containing 9
UCK2 uridine-cytidine kinase 2
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
WDR12 WD repeat domain 12
WIF1 WNT inhibitory factor 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing