BRD-K57080016_-666_RKO_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K57080016_-666_RKO_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ADIRF adipogenesis regulatory factor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CCL11 chemokine (C-C motif) ligand 11
CDC20 cell division cycle 20
CERS6 ceramide synthase 6
CES2 carboxylesterase 2
CHMP4A charged multivesicular body protein 4A
CLC Charcot-Leyden crystal galectin
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CRABP2 cellular retinoic acid binding protein 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL11 chemokine (C-X-C motif) ligand 11
CYTIP cytohesin 1 interacting protein
DCN decorin
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFHD1 EF-hand domain family, member D1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FOXF1 forkhead box F1
FOXF2 forkhead box F2
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
GAGE3 G antigen 3
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GPATCH8 G patch domain containing 8
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HEPH hephaestin
HIST1H2BG histone cluster 1, H2bg
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
ITGA8 integrin, alpha 8
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
MAN1A1 mannosidase, alpha, class 1A, member 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MMP12 matrix metallopeptidase 12
MPO myeloperoxidase
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NEBL nebulette
NID1 nidogen 1
ORC1 origin recognition complex, subunit 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCDH7 protocadherin 7
PCP4 Purkinje cell protein 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
POSTN periostin, osteoblast specific factor
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC38A1 solute carrier family 38, member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TPR translocated promoter region, nuclear basket protein
TSPAN7 tetraspanin 7
TST thiosulfate sulfurtransferase (rhodanese)
XIST X inactive specific transcript (non-protein coding)
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANKRD10 ankyrin repeat domain 10
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
C2CD2 C2 calcium-dependent domain containing 2
CAPNS1 calpain, small subunit 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CHERP calcium homeostasis endoplasmic reticulum protein
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
GOLM1 golgi membrane protein 1
GRWD1 glutamate-rich WD repeat containing 1
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
IER3 immediate early response 3
ITGB1BP1 integrin beta 1 binding protein 1
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LARP4 La ribonucleoprotein domain family, member 4
LIF leukemia inhibitory factor
LIMA1 LIM domain and actin binding 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MFSD12 major facilitator superfamily domain containing 12
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP88 nucleoporin 88kDa
ODC1 ornithine decarboxylase 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
PLS3 plastin 3
PNP purine nucleoside phosphorylase
PRMT1 protein arginine methyltransferase 1
PTGES prostaglandin E synthase
RPL36 ribosomal protein L36
RPS11 ribosomal protein S11
RPS21 ribosomal protein S21
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SPATS2L spermatogenesis associated, serine-rich 2-like
SRSF7 serine/arginine-rich splicing factor 7
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THADA thyroid adenoma associated
TLK2 tousled-like kinase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase