BRD-K57080016_-666_HA1E_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K57080016_-666_HA1E_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
ARG2 arginase 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
C1S complement component 1, s subcomponent
CD40 CD40 molecule, TNF receptor superfamily member 5
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGF epidermal growth factor
EPAS1 endothelial PAS domain protein 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPER1 G protein-coupled estrogen receptor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
LPL lipoprotein lipase
MNAT1 MNAT CDK-activating kinase assembly factor 1
NEB nebulin
NR1D2 nuclear receptor subfamily 1, group D, member 2
OSR2 odd-skipped related transciption factor 2
PALLD palladin, cytoskeletal associated protein
PCSK5 proprotein convertase subtilisin/kexin type 5
PPAP2A phosphatidic acid phosphatase type 2A
RCAN1 regulator of calcineurin 1
S100A9 S100 calcium binding protein A9
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
TCF4 transcription factor 4
TGFBR3 transforming growth factor, beta receptor III

decreased expression

Symbol Name
AK2 adenylate kinase 2
CAPG capping protein (actin filament), gelsolin-like
CCND1 cyclin D1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYTH1 cytohesin 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FOSL1 FOS-like antigen 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GCH1 GTP cyclohydrolase 1
HMGA2 high mobility group AT-hook 2
HOXB2 homeobox B2
IER3 immediate early response 3
IL6ST interleukin 6 signal transducer
LIF leukemia inhibitory factor
MLPH melanophilin
MOK MOK protein kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP16 NOP16 nucleolar protein
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRMT1 protein arginine methyltransferase 1
PTX3 pentraxin 3, long
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SOX9 SRY (sex determining region Y)-box 9
STEAP3 STEAP family member 3, metalloreductase
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
VNN1 vanin 1
ZNF91 zinc finger protein 91