BRD-K56751279_Y-39983_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K56751279_Y-39983_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ACTN2 actinin, alpha 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANGPT1 angiopoietin 1
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
CCK cholecystokinin
CFB complement factor B
CKM creatine kinase, muscle
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
COL15A1 collagen, type XV, alpha 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CXCL5 chemokine (C-X-C motif) ligand 5
DAPK1 death-associated protein kinase 1
DES desmin
ENO3 enolase 3 (beta, muscle)
FHL1 four and a half LIM domains 1
FXYD6 FXYD domain containing ion transport regulator 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB1BP1 integrin beta 1 binding protein 1
KCTD14 potassium channel tetramerization domain containing 14
KLHL41 kelch-like family member 41
LDB3 LIM domain binding 3
MT1F metallothionein 1F
MYBPC1 myosin binding protein C, slow type
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYOT myotilin
NEB nebulin
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE4DIP phosphodiesterase 4D interacting protein
PLN phospholamban
PRUNE prune exopolyphosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYGM phosphorylase, glycogen, muscle
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SLN sarcolipin
SMPX small muscle protein, X-linked
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCAP titin-cap
TFF1 trefoil factor 1
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)
TNNI1 troponin I type 1 (skeletal, slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM3 tropomyosin 3
TTN titin
TXNIP thioredoxin interacting protein
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARG1 arginase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL14 chemokine (C-X-C motif) ligand 14
DEFB1 defensin, beta 1
EZR ezrin
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
JMJD6 jumonji domain containing 6
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
LYN LYN proto-oncogene, Src family tyrosine kinase
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
PEX11A peroxisomal biogenesis factor 11 alpha
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXDN peroxidasin
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPP1 secreted phosphoprotein 1
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAMP8 vesicle-associated membrane protein 8
WSB1 WD repeat and SOCS box containing 1