BRD-K56593336_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K56593336_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACAT1 acetyl-CoA acetyltransferase 1
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
C1QB complement component 1, q subcomponent, B chain
C6ORF62 chromosome 6 open reading frame 62
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5A eukaryotic translation initiation factor 5A
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF1R insulin-like growth factor 1 receptor
IL1R2 interleukin 1 receptor, type II
KAT6B K(lysine) acetyltransferase 6B
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAMPT nicotinamide phosphoribosyltransferase
NMRK1 nicotinamide riboside kinase 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCSK6 proprotein convertase subtilisin/kexin type 6
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RPS21 ribosomal protein S21
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR3 small proline-rich protein 3
STC1 stanniocalcin 1
SULF1 sulfatase 1
TTN titin
TXNRD1 thioredoxin reductase 1
VCAN versican
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WT1 Wilms tumor 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
ANGPT1 angiopoietin 1
C2CD2 C2 calcium-dependent domain containing 2
CCL20 chemokine (C-C motif) ligand 20
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLMN calmin (calponin-like, transmembrane)
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DEPTOR DEP domain containing MTOR-interacting protein
DMD dystrophin
EIF3K eukaryotic translation initiation factor 3, subunit K
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP7 fatty acid binding protein 7, brain
FXYD5 FXYD domain containing ion transport regulator 5
GRB14 growth factor receptor-bound protein 14
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXC6 homeobox C6
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ISG15 ISG15 ubiquitin-like modifier
JADE2 jade family PHD finger 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAGED1 melanoma antigen family D1
MDK midkine (neurite growth-promoting factor 2)
MGLL monoglyceride lipase
MID1 midline 1
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MX1 MX dynamin-like GTPase 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLAGL1 pleiomorphic adenoma gene-like 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRAME preferentially expressed antigen in melanoma
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
TBCB tubulin folding cofactor B
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM147 transmembrane protein 147
TRIM22 tripartite motif containing 22
TSPYL5 TSPY-like 5
WFDC2 WAP four-disulfide core domain 2
ZNF318 zinc finger protein 318