BRD-K55502647_N-(2-methoxyphenyl)-4,6-dimorpholino-1,3,5-triazin-2-amine hw-gc-act06_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K55502647_N-(2-methoxyphenyl)-4,6-dimorpholino-1,3,5-triazin-2-amine hw-gc-act06_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AHNAK2 AHNAK nucleoprotein 2
APLP2 amyloid beta (A4) precursor-like protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CD24 CD24 molecule
CLDN3 claudin 3
COL3A1 collagen, type III, alpha 1
DSP desmoplakin
EGFR epidermal growth factor receptor
IFITM1 interferon induced transmembrane protein 1
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYO1D myosin ID
NEFL neurofilament, light polypeptide
OLFM4 olfactomedin 4
PFKL phosphofructokinase, liver
PID1 phosphotyrosine interaction domain containing 1
POMZP3 POM121 and ZP3 fusion
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BIN1 bridging integrator 1
CA12 carbonic anhydrase XII
CXCL8 chemokine (C-X-C motif) ligand 8
E2F2 E2F transcription factor 2
IRF4 interferon regulatory factor 4
LOC100505650 uncharacterized LOC100505650
MAGEA3 melanoma antigen family A3
MAOB monoamine oxidase B
MYO5C myosin VC
OSBPL3 oxysterol binding protein-like 3
P3H2 prolyl 3-hydroxylase 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK2 polo-like kinase 2
RAD23B RAD23 homolog B (S. cerevisiae)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPON2 spondin 2, extracellular matrix protein
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
ZBTB18 zinc finger and BTB domain containing 18
ZNF589 zinc finger protein 589