BRD-K55187425_ON-01910_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K55187425_ON-01910_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABHD2 abhydrolase domain containing 2
ACOT9 acyl-CoA thioesterase 9
ALCAM activated leukocyte cell adhesion molecule
ANKRD11 ankyrin repeat domain 11
ANXA3 annexin A3
ARHGAP6 Rho GTPase activating protein 6
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAG2 BCL2-associated athanogene 2
BPTF bromodomain PHD finger transcription factor
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD9 CD9 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CSRP1 cysteine and glycine-rich protein 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FHL2 four and a half LIM domains 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GRB10 growth factor receptor-bound protein 10
GSN gelsolin
IFRD1 interferon-related developmental regulator 1
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAPTM4B lysosomal protein transmembrane 4 beta
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKSL1 MARCKS-like 1
MAST2 microtubule associated serine/threonine kinase 2
MEIS1 Meis homeobox 1
MICALL1 MICAL-like 1
MT1E metallothionein 1E
MTCL1 microtubule crosslinking factor 1
MVP major vault protein
MXRA7 matrix-remodelling associated 7
OSBPL3 oxysterol binding protein-like 3
PAM peptidylglycine alpha-amidating monooxygenase
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PODXL podocalyxin-like
RALB v-ral simian leukemia viral oncogene homolog B
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMTN smoothelin
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
SRPX sushi-repeat containing protein, X-linked
SRRM2 serine/arginine repetitive matrix 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TOMM34 translocase of outer mitochondrial membrane 34
TPM4 tropomyosin 4
TUBA4A tubulin, alpha 4a
VAMP8 vesicle-associated membrane protein 8
VNN1 vanin 1
WSB2 WD repeat and SOCS box containing 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZYX zyxin

decreased expression

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
B3GNT1
BEX1 brain expressed, X-linked 1
C5 complement component 5
CA1 carbonic anhydrase I
CANX calnexin
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP4A charged multivesicular body protein 4A
CHN2 chimerin 2
CLU clusterin
CRIP2 cysteine-rich protein 2
EIF5A eukaryotic translation initiation factor 5A
EML4 echinoderm microtubule associated protein like 4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FMO5 flavin containing monooxygenase 5
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPC3 glypican 3
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
JAM3 junctional adhesion molecule 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTF lactotransferrin
MAOB monoamine oxidase B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
PAH phenylalanine hydroxylase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA6 protein disulfide isomerase family A, member 6
PGM1 phosphoglucomutase 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
RNASE4 ribonuclease, RNase A family, 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
XBP1 X-box binding protein 1