BRD-K54997624_BYL719_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K54997624_BYL719_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARID5B AT rich interactive domain 5B (MRF1-like)
BPHL biphenyl hydrolase-like (serine hydrolase)
C6ORF62 chromosome 6 open reading frame 62
CD46 CD46 molecule, complement regulatory protein
CD52 CD52 molecule
CHN1 chimerin 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST6 cystatin E/M
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSC1 desmocollin 1
DSP desmoplakin
FGFR3 fibroblast growth factor receptor 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
IDE insulin-degrading enzyme
ITGAV integrin, alpha V
KAT6B K(lysine) acetyltransferase 6B
LRRC17 leucine rich repeat containing 17
LUM lumican
NELL2 NEL-like 2 (chicken)
PTGES prostaglandin E synthase
QPCT glutaminyl-peptide cyclotransferase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
S100A7 S100 calcium binding protein A7
SST somatostatin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRBC1 T cell receptor beta constant 1
TSC22D1 TSC22 domain family, member 1
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA2P2 annexin A2 pseudogene 2
ANXA3 annexin A3
BID BH3 interacting domain death agonist
C1QA complement component 1, q subcomponent, A chain
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHGB chromogranin B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FGF9 fibroblast growth factor 9
HOXB2 homeobox B2
IGFBP4 insulin-like growth factor binding protein 4
KRT23 keratin 23, type I
KRT8 keratin 8, type II
MGLL monoglyceride lipase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PUF60 poly-U binding splicing factor 60KDa
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RNH1 ribonuclease/angiogenin inhibitor 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIX2 SIX homeobox 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOX11 SRY (sex determining region Y)-box 11
TUBA4A tubulin, alpha 4a