BRD-K54997624_BYL719_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K54997624_BYL719_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AHR aryl hydrocarbon receptor
AIM1 absent in melanoma 1
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAPG capping protein (actin filament), gelsolin-like
CCDC92 coiled-coil domain containing 92
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CFB complement factor B
CFD complement factor D (adipsin)
COPA coatomer protein complex, subunit alpha
CPD carboxypeptidase D
CSTA cystatin A (stefin A)
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
DRAM1 DNA-damage regulated autophagy modulator 1
EGFL6 EGF-like-domain, multiple 6
F5 coagulation factor V (proaccelerin, labile factor)
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GHR growth hormone receptor
GPATCH8 G patch domain containing 8
GRN granulin
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HNMT histamine N-methyltransferase
IFITM1 interferon induced transmembrane protein 1
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHDC10 kelch domain containing 10
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LIMK2 LIM domain kinase 2
LRP12 low density lipoprotein receptor-related protein 12
LY6E lymphocyte antigen 6 complex, locus E
MDFIC MyoD family inhibitor domain containing
MEIS1 Meis homeobox 1
MN1 meningioma (disrupted in balanced translocation) 1
MTMR11 myotubularin related protein 11
S100P S100 calcium binding protein P
SECISBP2L SECIS binding protein 2-like
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STC2 stanniocalcin 2
SULF1 sulfatase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TRIM22 tripartite motif containing 22
TSC22D1 TSC22 domain family, member 1
TST thiosulfate sulfurtransferase (rhodanese)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CALCA calcitonin-related polypeptide alpha
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CKB creatine kinase, brain
CRYAB crystallin, alpha B
CYR61 cysteine-rich, angiogenic inducer, 61
EBP emopamil binding protein (sterol isomerase)
EGFR epidermal growth factor receptor
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP7 fatty acid binding protein 7, brain
GLIPR1 GLI pathogenesis-related 1
GUSBP11 glucuronidase, beta pseudogene 11
HN1 hematological and neurological expressed 1
HOXC10 homeobox C10
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
LRRC17 leucine rich repeat containing 17
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NEK2 NIMA-related kinase 2
NPY1R neuropeptide Y receptor Y1
PKN2 protein kinase N2
PLK1 polo-like kinase 1
RBP1 retinol binding protein 1, cellular
S100A2 S100 calcium binding protein A2
SET SET nuclear proto-oncogene
SLPI secretory leukocyte peptidase inhibitor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S