BRD-K54997624_BYL719_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K54997624_BYL719_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASCL1 achaete-scute family bHLH transcription factor 1
BAALC brain and acute leukemia, cytoplasmic
BCL2 B-cell CLL/lymphoma 2
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
CALB1 calbindin 1, 28kDa
CCR2 chemokine (C-C motif) receptor 2
CHN1 chimerin 1
CLGN calmegin
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DIXDC1 DIX domain containing 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL3 dihydropyrimidinase-like 3
ETV1 ets variant 1
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPATCH8 G patch domain containing 8
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEPH hephaestin
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL7R interleukin 7 receptor
KIF5C kinesin family member 5C
KRT81 keratin 81, type II
LRRC16A leucine rich repeat containing 16A
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NEBL nebulette
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE10A phosphodiesterase 10A
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SLC38A1 solute carrier family 38, member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SYNM synemin, intermediate filament protein
TF transferrin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOX3 TOX high mobility group box family member 3
TSPAN8 tetraspanin 8
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ADRB2 adrenoceptor beta 2, surface
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ASPH aspartate beta-hydroxylase
ASPN asporin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CDC42 cell division cycle 42
ECM1 extracellular matrix protein 1
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
HAMP hepcidin antimicrobial peptide
HIRA histone cell cycle regulator
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MMP9 matrix metallopeptidase 9
NBL1 neuroblastoma 1, DAN family BMP antagonist
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXN nucleoredoxin
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTPRC protein tyrosine phosphatase, receptor type, C
PXDN peroxidasin
SATB1 SATB homeobox 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPON2 spondin 2, extracellular matrix protein
TOB1 transducer of ERBB2, 1
TXN thioredoxin
TYROBP TYRO protein tyrosine kinase binding protein
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)