BRD-K54997624_BYL719_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K54997624_BYL719_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
APOLD1 apolipoprotein L domain containing 1
ARMCX1 armadillo repeat containing, X-linked 1
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COMT catechol-O-methyltransferase
CTGF connective tissue growth factor
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIAPH2 diaphanous-related formin 2
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENGASE endo-beta-N-acetylglucosaminidase
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXO4 forkhead box O4
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GSN gelsolin
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMO2 LIM domain only 2 (rhombotin-like 1)
LXN latexin
LY75 lymphocyte antigen 75
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBNL2 muscleblind-like splicing regulator 2
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORAI3 ORAI calcium release-activated calcium modulator 3
PARP4 poly (ADP-ribose) polymerase family, member 4
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLCB4 phospholipase C, beta 4
PLSCR4 phospholipid scramblase 4
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTCH1 patched 1
PTPRK protein tyrosine phosphatase, receptor type, K
QARS glutaminyl-tRNA synthetase
RAP1GAP RAP1 GTPase activating protein
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
S100A11 S100 calcium binding protein A11
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35E2B solute carrier family 35, member E2B
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
USP34 ubiquitin specific peptidase 34
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
YPEL5 yippee-like 5 (Drosophila)
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPN centromere protein N
CHEK2 checkpoint kinase 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CXCL14 chemokine (C-X-C motif) ligand 14
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KIF20A kinesin family member 20A
KRT17 keratin 17, type I
MAL mal, T-cell differentiation protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
PBK PDZ binding kinase
PEG10 paternally expressed 10
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RFC3 replication factor C (activator 1) 3, 38kDa
S100A2 S100 calcium binding protein A2
SIVA1 SIVA1, apoptosis-inducing factor
SMAD1 SMAD family member 1
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SUB1 SUB1 homolog (S. cerevisiae)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMPO thymopoietin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)