BRD-K54997624_BYL719_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K54997624_BYL719_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOX2 acyl-CoA oxidase 2, branched chain
ADAMDEC1 ADAM-like, decysin 1
AGTR1 angiotensin II receptor, type 1
AKR1C3 aldo-keto reductase family 1, member C3
ANG angiogenin, ribonuclease, RNase A family, 5
ANKRD36B ankyrin repeat domain 36B
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C10ORF10 chromosome 10 open reading frame 10
C1ORF115 chromosome 1 open reading frame 115
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFB complement factor B
CHGB chromogranin B
CLU clusterin
COBL cordon-bleu WH2 repeat protein
CP ceruloplasmin (ferroxidase)
CREG1 cellular repressor of E1A-stimulated genes 1
CRISP3 cysteine-rich secretory protein 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CYFIP2 cytoplasmic FMR1 interacting protein 2
EMX2 empty spiracles homeobox 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FGF9 fibroblast growth factor 9
FXYD3 FXYD domain containing ion transport regulator 3
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPX3 glutathione peroxidase 3
GRAMD1C GRAM domain containing 1C
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
H1F0 H1 histone family, member 0
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
KANK1 KN motif and ankyrin repeat domains 1
LEPR leptin receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LXN latexin
LYZ lysozyme
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
NDRG2 NDRG family member 2
PDGFRL platelet-derived growth factor receptor-like
PDLIM5 PDZ and LIM domain 5
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR4 phospholipid scramblase 4
PLVAP plasmalemma vesicle associated protein
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PROM1 prominin 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS5 regulator of G-protein signaling 5
RNF144A ring finger protein 144A
S100P S100 calcium binding protein P
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SORBS2 sorbin and SH3 domain containing 2
TARP TCR gamma alternate reading frame protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
AREG amphiregulin
BHLHE40 basic helix-loop-helix family, member e40
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
DDIT4 DNA-damage-inducible transcript 4
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
G0S2 G0/G1 switch 2
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KRT19 keratin 19, type I
MAGEA3 melanoma antigen family A3
NLRP2 NLR family, pyrin domain containing 2
NUP85 nucleoporin 85kDa
ODC1 ornithine decarboxylase 1
OLFM1 olfactomedin 1
POSTN periostin, osteoblast specific factor
RAD23B RAD23 homolog B (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLIT2 slit homolog 2 (Drosophila)
SLN sarcolipin
TAGLN2 transgelin 2
TNC tenascin C
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1