BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CCND1 cyclin D1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DIDO1 death inducer-obliterator 1
EMP1 epithelial membrane protein 1
EZR ezrin
FABP7 fatty acid binding protein 7, brain
FERMT2 fermitin family member 2
FGL2 fibrinogen-like 2
FOXF1 forkhead box F1
GLS glutaminase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IL7R interleukin 7 receptor
KLF6 Kruppel-like factor 6
KLHL7 kelch-like family member 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
NFIL3 nuclear factor, interleukin 3 regulated
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCIF1 PDX1 C-terminal inhibiting factor 1
POSTN periostin, osteoblast specific factor
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SELT selenoprotein T
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNRK SNF related kinase
SST somatostatin
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATMIN ATM interactor
BRCA1 breast cancer 1, early onset
CEMIP cell migration inducing protein, hyaluronan binding
CNOT4 CCR4-NOT transcription complex, subunit 4
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
ETFB electron-transfer-flavoprotein, beta polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
GAGE3 G antigen 3
GPX2 glutathione peroxidase 2
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HMMR hyaluronan-mediated motility receptor (RHAMM)
JADE2 jade family PHD finger 2
LACTB2 lactamase, beta 2
LRRC16A leucine rich repeat containing 16A
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MGP matrix Gla protein
MTA1 metastasis associated 1
NISCH nischarin
NMT1 N-myristoyltransferase 1
NNMT nicotinamide N-methyltransferase
NUP62 nucleoporin 62kDa
PPP1R10 protein phosphatase 1, regulatory subunit 10
RAB13 RAB13, member RAS oncogene family
RSL1D1 ribosomal L1 domain containing 1
S100A9 S100 calcium binding protein A9
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCERG1 transcription elongation regulator 1
TMEM5 transmembrane protein 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE3C ubiquitin protein ligase E3C