BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNC cyclin C
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLEC2B C-type lectin domain family 2, member B
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDIT4 DNA-damage-inducible transcript 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFHD1 EF-hand domain family, member D1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FERMT2 fermitin family member 2
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KRT14 keratin 14, type I
LAPTM4A lysosomal protein transmembrane 4 alpha
LBR lamin B receptor
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
NTAN1 N-terminal asparagine amidase
PARP2 poly (ADP-ribose) polymerase 2
PFN2 profilin 2
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
RAB1A RAB1A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
RTN4 reticulon 4
RYBP RING1 and YY1 binding protein
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SERTAD2 SERTA domain containing 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SOX9 SRY (sex determining region Y)-box 9
STMN1 stathmin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C

decreased expression

Symbol Name
APRT adenine phosphoribosyltransferase
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C2CD5 C2 calcium-dependent domain containing 5
CALB1 calbindin 1, 28kDa
CCDC85B coiled-coil domain containing 85B
CD320 CD320 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CLDN10 claudin 10
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPRS glutamyl-prolyl-tRNA synthetase
ETFB electron-transfer-flavoprotein, beta polypeptide
FAR2 fatty acyl CoA reductase 2
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT13 keratin 13, type I
LAMA3 laminin, alpha 3
LCN2 lipocalin 2
LXN latexin
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K5 mitogen-activated protein kinase kinase kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MRPS2 mitochondrial ribosomal protein S2
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOP16 NOP16 nucleolar protein
NTS neurotensin
PFKM phosphofructokinase, muscle
PIEZO1 piezo-type mechanosensitive ion channel component 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PUS7 pseudouridylate synthase 7 (putative)
RNASE6 ribonuclease, RNase A family, k6
RNMTL1 RNA methyltransferase like 1
RPL22 ribosomal protein L22
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SPON1 spondin 1, extracellular matrix protein
ST7 suppression of tumorigenicity 7
TNIK TRAF2 and NCK interacting kinase
TPI1 triosephosphate isomerase 1
TRIP6 thyroid hormone receptor interactor 6
YBX3 Y box binding protein 3