BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASPN asporin
CD24 CD24 molecule
CD48 CD48 molecule
CD52 CD52 molecule
CKB creatine kinase, brain
CSTA cystatin A (stefin A)
DLX5 distal-less homeobox 5
DUSP1 dual specificity phosphatase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FASTKD5 FAST kinase domains 5
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
GSN gelsolin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGF1 insulin-like growth factor 1 (somatomedin C)
JAG1 jagged 1
KLF10 Kruppel-like factor 10
KRT5 keratin 5, type II
LCN2 lipocalin 2
LYZ lysozyme
MB myoglobin
MCUR1 mitochondrial calcium uniporter regulator 1
MDK midkine (neurite growth-promoting factor 2)
MPO myeloperoxidase
MSMB microseminoprotein, beta-
NEFH neurofilament, heavy polypeptide
PAK1IP1 PAK1 interacting protein 1
PEG10 paternally expressed 10
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRNP prion protein
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGB2A1 secretoglobin, family 2A, member 1
SEPT2 septin 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TGFB1 transforming growth factor, beta 1
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
ANKRD36B ankyrin repeat domain 36B
ASS1 argininosuccinate synthase 1
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CDC25B cell division cycle 25B
CDK12 cyclin-dependent kinase 12
CSAD cysteine sulfinic acid decarboxylase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DHRS2 dehydrogenase/reductase (SDR family) member 2
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
LPL lipoprotein lipase
LYST lysosomal trafficking regulator
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
N4BP2L2 NEDD4 binding protein 2-like 2
NCAM1 neural cell adhesion molecule 1
NFX1 nuclear transcription factor, X-box binding 1
NMT1 N-myristoyltransferase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
PDE10A phosphodiesterase 10A
RBM26 RNA binding motif protein 26
RNMT RNA (guanine-7-) methyltransferase
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETX senataxin
TCERG1 transcription elongation regulator 1
TFF3 trefoil factor 3 (intestinal)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
ZMYM2 zinc finger, MYM-type 2