BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDOC aldolase C, fructose-bisphosphate
ASPN asporin
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC5 chloride intracellular channel 5
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
DCLK1 doublecortin-like kinase 1
DPYSL3 dihydropyrimidinase-like 3
EMP1 epithelial membrane protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GLIPR1 GLI pathogenesis-related 1
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INHBA inhibin, beta A
ITM2C integral membrane protein 2C
JAG1 jagged 1
KLF6 Kruppel-like factor 6
LRRC15 leucine rich repeat containing 15
MCOLN1 mucolipin 1
MIR22HG MIR22 host gene
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKCI protein kinase C, iota
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RYBP RING1 and YY1 binding protein
SDC2 syndecan 2
SERINC3 serine incorporator 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOX4 SRY (sex determining region Y)-box 4
STAB1 stabilin 1
TCF4 transcription factor 4
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
WISP2 WNT1 inducible signaling pathway protein 2
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ACO1 aconitase 1, soluble
AK1 adenylate kinase 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARFIP2 ADP-ribosylation factor interacting protein 2
ASCC3 activating signal cointegrator 1 complex subunit 3
CALR calreticulin
CD44 CD44 molecule (Indian blood group)
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CNPY2 canopy FGF signaling regulator 2
COG4 component of oligomeric golgi complex 4
DESI1 desumoylating isopeptidase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EHBP1 EH domain binding protein 1
ETFB electron-transfer-flavoprotein, beta polypeptide
EXOSC8 exosome component 8
FBXO9 F-box protein 9
GOLGA8A golgin A8 family, member A
HDDC2 HD domain containing 2
HOXC6 homeobox C6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KPNB1 karyopherin (importin) beta 1
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LOXL1 lysyl oxidase-like 1
LRP10 low density lipoprotein receptor-related protein 10
MANSC1 MANSC domain containing 1
MAPK13 mitogen-activated protein kinase 13
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MRPL57 mitochondrial ribosomal protein L57
MRPS16 mitochondrial ribosomal protein S16
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NQO1 NAD(P)H dehydrogenase, quinone 1
NUP43 nucleoporin 43kDa
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXA1L oxidase (cytochrome c) assembly 1-like
PFKM phosphofructokinase, muscle
PITX1 paired-like homeodomain 1
PLSCR3 phospholipid scramblase 3
PNKP polynucleotide kinase 3'-phosphatase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PROM1 prominin 1
RAD9A RAD9 homolog A (S. pombe)
RFC2 replication factor C (activator 1) 2, 40kDa
RWDD2B RWD domain containing 2B
SFRP1 secreted frizzled-related protein 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUB1 SUB1 homolog (S. cerevisiae)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM5 transmembrane protein 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOM1L1 target of myb1 (chicken)-like 1
TPCN1 two pore segment channel 1
TRIP6 thyroid hormone receptor interactor 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
VWA8 von Willebrand factor A domain containing 8