BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
APLP2 amyloid beta (A4) precursor-like protein 2
ARG1 arginase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BCL2A1 BCL2-related protein A1
CCK cholecystokinin
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DEFA4 defensin, alpha 4, corticostatin
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
JAG1 jagged 1
KLF10 Kruppel-like factor 10
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NEBL nebulette
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
OLFM4 olfactomedin 4
PDE2A phosphodiesterase 2A, cGMP-stimulated
PLAGL1 pleiomorphic adenoma gene-like 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSAP prosaposin
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SMYD2 SET and MYND domain containing 2
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STXBP6 syntaxin binding protein 6 (amisyn)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TPSAB1 tryptase alpha/beta 1
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
WASF3 WAS protein family, member 3
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ADGRG6 adhesion G protein-coupled receptor G6
AKAP9 A kinase (PRKA) anchor protein 9
ANKRD17 ankyrin repeat domain 17
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATR ATR serine/threonine kinase
ATXN1 ataxin 1
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
CALD1 caldesmon 1
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK12 cyclin-dependent kinase 12
CDK14 cyclin-dependent kinase 14
CEMIP cell migration inducing protein, hyaluronan binding
CEP192 centrosomal protein 192kDa
CHD9 chromodomain helicase DNA binding protein 9
CHIC2 cysteine-rich hydrophobic domain 2
CPD carboxypeptidase D
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DST dystonin
EDRF1 erythroid differentiation regulatory factor 1
EHBP1 EH domain binding protein 1
EIF5A eukaryotic translation initiation factor 5A
FAM208A family with sequence similarity 208, member A
FAM216A family with sequence similarity 216, member A
FCGBP Fc fragment of IgG binding protein
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLS glutaminase
GOLGA8A golgin A8 family, member A
GSAP gamma-secretase activating protein
GSTA4 glutathione S-transferase alpha 4
HOPX HOP homeobox
HOXC6 homeobox C6
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
INTS8 integrator complex subunit 8
JMJD6 jumonji domain containing 6
KIAA1033 KIAA1033
LAMB1 laminin, beta 1
LARP4 La ribonucleoprotein domain family, member 4
LGALS8 lectin, galactoside-binding, soluble, 8
LYST lysosomal trafficking regulator
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MTCL1 microtubule crosslinking factor 1
MX2 MX dynamin-like GTPase 2
N4BP2L2 NEDD4 binding protein 2-like 2
NMT1 N-myristoyltransferase 1
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PDS5A PDS5 cohesin associated factor A
PHF11 PHD finger protein 11
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SENP6 SUMO1/sentrin specific peptidase 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPG11 spastic paraplegia 11 (autosomal recessive)
SYNJ2 synaptojanin 2
SYNRG synergin, gamma
TBC1D31 TBC1 domain family, member 31
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCERG1 transcription elongation regulator 1
THOC2 THO complex 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX3 TOX high mobility group box family member 3
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
UBE3C ubiquitin protein ligase E3C
ZNF451 zinc finger protein 451