BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APLP2 amyloid beta (A4) precursor-like protein 2
CAMP cathelicidin antimicrobial peptide
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
CST3 cystatin C
DLK1 delta-like 1 homolog (Drosophila)
ELL2 elongation factor, RNA polymerase II, 2
EPAS1 endothelial PAS domain protein 1
FAM171A1 family with sequence similarity 171, member A1
FASTKD5 FAST kinase domains 5
FN1 fibronectin 1
GSN gelsolin
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IRX5 iroquois homeobox 5
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LYZ lysozyme
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
OLFM4 olfactomedin 4
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
S100A8 S100 calcium binding protein A8
TMSB15A thymosin beta 15a
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
BRCA1 breast cancer 1, early onset
C2CD5 C2 calcium-dependent domain containing 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CP ceruloplasmin (ferroxidase)
DEPTOR DEP domain containing MTOR-interacting protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTF3A general transcription factor IIIA
HOPX HOP homeobox
KRT7 keratin 7, type II
LACTB2 lactamase, beta 2
MAOA monoamine oxidase A
ORC1 origin recognition complex, subunit 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
POSTN periostin, osteoblast specific factor
RPL31 ribosomal protein L31
SNX10 sorting nexin 10
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TBC1D31 TBC1 domain family, member 31
THBS2 thrombospondin 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM176B transmembrane protein 176B
TMEM5 transmembrane protein 5
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit