BRD-K54606188_(+)-JQ1_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

225 genes differentially expressed following the BRD-K54606188_(+)-JQ1_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLNK B-cell linker
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
C9ORF3 chromosome 9 open reading frame 3
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALCA calcitonin-related polypeptide alpha
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLIC3 chloride intracellular channel 3
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRIP1 cysteine-rich protein 1 (intestinal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EZR ezrin
FADS3 fatty acid desaturase 3
FAM46A family with sequence similarity 46, member A
FAM50A family with sequence similarity 50, member A
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GDI1 GDP dissociation inhibitor 1
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSDMB gasdermin B
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HCP5 HLA complex P5 (non-protein coding)
HEPH hephaestin
HIP1R huntingtin interacting protein 1 related
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IQCG IQ motif containing G
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0226 KIAA0226
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP4 low density lipoprotein receptor-related protein 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCAM melanoma cell adhesion molecule
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MXRA7 matrix-remodelling associated 7
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NDNF neuron-derived neurotrophic factor
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NLRP2 NLR family, pyrin domain containing 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
OSR2 odd-skipped related transciption factor 2
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCDH17 protocadherin 17
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PNKP polynucleotide kinase 3'-phosphatase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTPRD protein tyrosine phosphatase, receptor type, D
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCOR1 REST corepressor 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN3 reticulon 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPT10 septin 10
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SF1 splicing factor 1
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SPATA2L spermatogenesis associated 2-like
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP1 syntaxin binding protein 1
TBX3 T-box 3
TFF1 trefoil factor 1
TM7SF2 transmembrane 7 superfamily member 2
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TSC22D2 TSC22 domain family, member 2
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCL vinculin
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
C1ORF106 chromosome 1 open reading frame 106
C3 complement component 3
CA12 carbonic anhydrase XII
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRYZ crystallin, zeta (quinone reductase)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EREG epiregulin
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPR171 G protein-coupled receptor 171
GYPC glycophorin C (Gerbich blood group)
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB1 heat shock 27kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IL1B interleukin 1, beta
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
LAPTM5 lysosomal protein transmembrane 5
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAPK13 mitogen-activated protein kinase 13
MGST2 microsomal glutathione S-transferase 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NREP neuronal regeneration related protein
NRP1 neuropilin 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PLIN3 perilipin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51AP1 RAD51 associated protein 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RDX radixin
RFTN1 raftlin, lipid raft linker 1
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SHCBP1 SHC SH2-domain binding protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN2 transgelin 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRIM14 tripartite motif containing 14
TSPAN4 tetraspanin 4
UBE2E1 ubiquitin-conjugating enzyme E2E 1
VCAN versican
VGLL4 vestigial-like family member 4
XIST X inactive specific transcript (non-protein coding)
ZHX2 zinc fingers and homeoboxes 2
ZNF22 zinc finger protein 22