BRD-K54606188_(+)-JQ1_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K54606188_(+)-JQ1_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADCY9 adenylate cyclase 9
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANO10 anoctamin 10
ARHGAP29 Rho GTPase activating protein 29
ARL8B ADP-ribosylation factor-like 8B
ASMTL acetylserotonin O-methyltransferase-like
ATOX1 antioxidant 1 copper chaperone
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW2 basic leucine zipper and W2 domains 2
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CIRBP cold inducible RNA binding protein
CLIC3 chloride intracellular channel 3
CLIC4 chloride intracellular channel 4
CPNE3 copine III
CTSA cathepsin A
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EMC3 ER membrane protein complex subunit 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GABARAPL2 GABA(A) receptor-associated protein-like 2
GALC galactosylceramidase
GM2A GM2 ganglioside activator
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GRN granulin
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
INPP5F inositol polyphosphate-5-phosphatase F
KDM5A lysine (K)-specific demethylase 5A
KIAA1033 KIAA1033
KLHL24 kelch-like family member 24
KRT6A keratin 6A, type II
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGMN legumain
LMO2 LIM domain only 2 (rhombotin-like 1)
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MYLIP myosin regulatory light chain interacting protein
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
PALLD palladin, cytoskeletal associated protein
PCYOX1 prenylcysteine oxidase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRAF2 PRA1 domain family, member 2
RAP2A RAP2A, member of RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RHOA ras homolog family member A
RHOB ras homolog family member B
RRAGC Ras-related GTP binding C
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SCG2 secretogranin II
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SQSTM1 sequestosome 1
STOM stomatin
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM7SF2 transmembrane 7 superfamily member 2
TMEM50A transmembrane protein 50A
TMOD1 tropomodulin 1
TPP1 tripeptidyl peptidase I
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
WDR47 WD repeat domain 47
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP3 aquaporin 3 (Gill blood group)
ATF1 activating transcription factor 1
ATF4 activating transcription factor 4
BAD BCL2-associated agonist of cell death
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
C1R complement component 1, r subcomponent
C8ORF4 chromosome 8 open reading frame 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD1E CD1e molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
COL15A1 collagen, type XV, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
CRLF1 cytokine receptor-like factor 1
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK10 dedicator of cytokinesis 10
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FAM129A family with sequence similarity 129, member A
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GOLT1B golgi transport 1B
GPR171 G protein-coupled receptor 171
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI16 interferon, gamma-inducible protein 16
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IL17RB interleukin 17 receptor B
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KLF4 Kruppel-like factor 4 (gut)
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MAPK13 mitogen-activated protein kinase 13
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDP Norrie disease (pseudoglioma)
NMI N-myc (and STAT) interactor
ORC1 origin recognition complex, subunit 1
P3H2 prolyl 3-hydroxylase 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCOLCE procollagen C-endopeptidase enhancer
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RAB20 RAB20, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RBM47 RNA binding motif protein 47
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SORBS2 sorbin and SH3 domain containing 2
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZWINT ZW10 interacting kinetochore protein