BRD-K54256913_MK-1775_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K54256913_MK-1775_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSF2 acyl-CoA synthetase family member 2
AGTR1 angiotensin II receptor, type 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
ANXA2 annexin A2
APOD apolipoprotein D
CD14 CD14 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FDXR ferredoxin reductase
FOSL1 FOS-like antigen 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
IRS1 insulin receptor substrate 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MEG3 maternally expressed 3 (non-protein coding)
MEIS1 Meis homeobox 1
MIR22HG MIR22 host gene
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
PEG3 paternally expressed 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PSD3 pleckstrin and Sec7 domain containing 3
RAB40B RAB40B, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
TIMP1 TIMP metallopeptidase inhibitor 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPM2 tropomyosin 2 (beta)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
BACE2 beta-site APP-cleaving enzyme 2
BARD1 BRCA1 associated RING domain 1
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
CCNE2 cyclin E2
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CXCL14 chemokine (C-X-C motif) ligand 14
EIF5 eukaryotic translation initiation factor 5
ENO1 enolase 1, (alpha)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPC3 glypican 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
MELK maternal embryonic leucine zipper kinase
MFAP2 microfibrillar-associated protein 2
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RFC2 replication factor C (activator 1) 2, 40kDa
TMPO thymopoietin
TYRP1 tyrosinase-related protein 1
VGLL4 vestigial-like family member 4
XIST X inactive specific transcript (non-protein coding)