BRD-K54256913_MK-1775_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K54256913_MK-1775_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BST2 bone marrow stromal cell antigen 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CIRBP cold inducible RNA binding protein
CLSTN1 calsyntenin 1
CSRP2 cysteine and glycine-rich protein 2
CTSH cathepsin H
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DST dystonin
EBP emopamil binding protein (sterol isomerase)
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCMR Fc fragment of IgM receptor
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMG20B high mobility group 20B
HOPX HOP homeobox
IGHM immunoglobulin heavy constant mu
KIAA0226L KIAA0226-like
KIF14 kinesin family member 14
KPNB1 karyopherin (importin) beta 1
KRT17 keratin 17, type I
LTF lactotransferrin
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
NCF1C neutrophil cytosolic factor 1C pseudogene
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PEBP1 phosphatidylethanolamine binding protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PRDX2 peroxiredoxin 2
PRF1 perforin 1 (pore forming protein)
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSRC1 proline/serine-rich coiled-coil 1
RGS1 regulator of G-protein signaling 1
S100A2 S100 calcium binding protein A2
SDPR serum deprivation response
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TCL1A T-cell leukemia/lymphoma 1A
TIMP1 TIMP metallopeptidase inhibitor 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C10ORF10 chromosome 10 open reading frame 10
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CPM carboxypeptidase M
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFNB2 ephrin-B2
FAR2 fatty acyl CoA reductase 2
FRZB frizzled-related protein
GALC galactosylceramidase
GATA6 GATA binding protein 6
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HES1 hes family bHLH transcription factor 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
JAG1 jagged 1
KIAA0101 KIAA0101
MDK midkine (neurite growth-promoting factor 2)
MN1 meningioma (disrupted in balanced translocation) 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NET1 neuroepithelial cell transforming 1
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
OSR2 odd-skipped related transciption factor 2
PDGFC platelet derived growth factor C
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMAL1 paraneoplastic Ma antigen family-like 1
PRAME preferentially expressed antigen in melanoma
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSPN sarcospan
SST somatostatin
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNS3 tensin 3
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1