BRD-K54256913_MK-1775_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K54256913_MK-1775_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACBD3 acyl-CoA binding domain containing 3
ADGRG1 adhesion G protein-coupled receptor G1
AKAP8L A kinase (PRKA) anchor protein 8-like
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
CCND2 cyclin D2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
CST3 cystatin C
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEGS1 delta(4)-desaturase, sphingolipid 1
DFNA5 deafness, autosomal dominant 5
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EMC7 ER membrane protein complex subunit 7
FABP4 fatty acid binding protein 4, adipocyte
FDXR ferredoxin reductase
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GRN granulin
GSN gelsolin
HIPK1 homeodomain interacting protein kinase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL6ST interleukin 6 signal transducer
INPP1 inositol polyphosphate-1-phosphatase
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LAMP1 lysosomal-associated membrane protein 1
LGALS1 lectin, galactoside-binding, soluble, 1
LRP10 low density lipoprotein receptor-related protein 10
M6PR mannose-6-phosphate receptor (cation dependent)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICALL1 MICAL-like 1
MLF2 myeloid leukemia factor 2
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MVP major vault protein
NEU1 sialidase 1 (lysosomal sialidase)
NNMT nicotinamide N-methyltransferase
NOSIP nitric oxide synthase interacting protein
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
PALLD palladin, cytoskeletal associated protein
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRNP prion protein
PROCR protein C receptor, endothelial
PROM1 prominin 1
QPCT glutaminyl-peptide cyclotransferase
RBKS ribokinase
RBPMS RNA binding protein with multiple splicing
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFN stratifin
SFXN3 sideroflexin 3
SLC22A18 solute carrier family 22, member 18
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMAD3 SMAD family member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
SVIL supervillin
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TM4SF1 transmembrane 4 L six family member 1
TMPRSS2 transmembrane protease, serine 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TUBB6 tubulin, beta 6 class V
TWF2 twinfilin actin binding protein 2
WNK1 WNK lysine deficient protein kinase 1
YBX3 Y box binding protein 3
ZBTB38 zinc finger and BTB domain containing 38
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP1 aquaporin 1 (Colton blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CCNE1 cyclin E1
CD36 CD36 molecule (thrombospondin receptor)
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DICER1 dicer 1, ribonuclease type III
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMTF1 cyclin D binding myb-like transcription factor 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELN elastin
EXO1 exonuclease 1
FEN1 flap structure-specific endonuclease 1
FRZB frizzled-related protein
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
HMGB2 high mobility group box 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KNG1 kininogen 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MELK maternal embryonic leucine zipper kinase
MFSD10 major facilitator superfamily domain containing 10
MUC16 mucin 16, cell surface associated
NAMPT nicotinamide phosphoribosyltransferase
NEFM neurofilament, medium polypeptide
NOTCH3 notch 3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PAPD7 PAP associated domain containing 7
PBK PDZ binding kinase
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PXMP2 peroxisomal membrane protein 2, 22kDa
RELN reelin
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLBP stem-loop binding protein
SMAD1 SMAD family member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TCTN1 tectonic family member 1
TEX30 testis expressed 30
TFRC transferrin receptor
THY1 Thy-1 cell surface antigen
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
ZWINT ZW10 interacting kinetochore protein