BRD-K53972329_ruxolitinib_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K53972329_ruxolitinib_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
C10ORF10 chromosome 10 open reading frame 10
CPE carboxypeptidase E
CRTAP cartilage associated protein
EID1 EP300 interacting inhibitor of differentiation 1
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
KIAA0101 KIAA0101
KLHDC10 kelch domain containing 10
PSAP prosaposin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SKAP2 src kinase associated phosphoprotein 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TSC22D1 TSC22 domain family, member 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
AQP3 aquaporin 3 (Gill blood group)
CLDN10 claudin 10
COCH cochlin
COL1A1 collagen, type I, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DLK1 delta-like 1 homolog (Drosophila)
ELOVL2 ELOVL fatty acid elongase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
GLDC glycine dehydrogenase (decarboxylating)
H3F3B H3 histone, family 3B (H3.3B)
HNRNPL heterogeneous nuclear ribonucleoprotein L
LEF1 lymphoid enhancer-binding factor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
PHACTR1 phosphatase and actin regulator 1
PPARG peroxisome proliferator-activated receptor gamma
RBMS1 RNA binding motif, single stranded interacting protein 1
RGS4 regulator of G-protein signaling 4
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
STC2 stanniocalcin 2
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
WNT5A wingless-type MMTV integration site family, member 5A