BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
CBR3 carbonyl reductase 3
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
COL11A1 collagen, type XI, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP14 dual specificity phosphatase 14
E2F2 E2F transcription factor 2
EFHD1 EF-hand domain family, member D1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GALC galactosylceramidase
GLA galactosidase, alpha
GLUL glutamate-ammonia ligase
GSTP1 glutathione S-transferase pi 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HSPB8 heat shock 22kDa protein 8
IER5 immediate early response 5
LMO4 LIM domain only 4
MOK MOK protein kinase
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
NDRG2 NDRG family member 2
PALLD palladin, cytoskeletal associated protein
PCDH17 protocadherin 17
PEA15 phosphoprotein enriched in astrocytes 15
PLAU plasminogen activator, urokinase
PMP22 peripheral myelin protein 22
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXN paxillin
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDC4 syndecan 4
SGK1 serum/glucocorticoid regulated kinase 1
SMAD3 SMAD family member 3
SOCS2 suppressor of cytokine signaling 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIMP1 TIMP metallopeptidase inhibitor 1
TRIP6 thyroid hormone receptor interactor 6
TUBB2A tubulin, beta 2A class IIa
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VGLL4 vestigial-like family member 4
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOX2 acyl-CoA oxidase 2, branched chain
AK4 adenylate kinase 4
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
AUH AU RNA binding protein/enoyl-CoA hydratase
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CA12 carbonic anhydrase XII
CANX calnexin
CCNG1 cyclin G1
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFI complement factor I
CTSZ cathepsin Z
DARS aspartyl-tRNA synthetase
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EBP emopamil binding protein (sterol isomerase)
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FADS2 fatty acid desaturase 2
GNAS GNAS complex locus
GRB14 growth factor receptor-bound protein 14
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFITM2 interferon induced transmembrane protein 2
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
KIF20A kinesin family member 20A
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NHP2 NHP2 ribonucleoprotein
NLGN4X neuroligin 4, X-linked
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPDC1 neural proliferation, differentiation and control, 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSG1 neuron specific gene family member 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCCB propionyl CoA carboxylase, beta polypeptide
PDGFC platelet derived growth factor C
PDIA6 protein disulfide isomerase family A, member 6
PEG3 paternally expressed 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPA2 pyrophosphatase (inorganic) 2
PRR7 proline rich 7 (synaptic)
QPRT quinolinate phosphoribosyltransferase
RAB4A RAB4A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REXO2 RNA exonuclease 2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC61B Sec61 beta subunit
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
SSR4 signal sequence receptor, delta
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST7 suppression of tumorigenicity 7
STK26 serine/threonine protein kinase 26
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOR1A torsin family 1, member A (torsin A)
TPD52L1 tumor protein D52-like 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VLDLR very low density lipoprotein receptor
WNT5A wingless-type MMTV integration site family, member 5A