BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG3 BTG family, member 3
CCNL1 cyclin L1
CD69 CD69 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHIC2 cysteine-rich hydrophobic domain 2
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DLC1 DLC1 Rho GTPase activating protein
FAM46C family with sequence similarity 46, member C
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IRF9 interferon regulatory factor 9
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1M metallothionein 1M
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAF2 PRA1 domain family, member 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCG5 secretogranin V
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOMM34 translocase of outer mitochondrial membrane 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CAV2 caveolin 2
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DST dystonin
FAM3C family with sequence similarity 3, member C
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIAA0101 KIAA0101
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
MDFIC MyoD family inhibitor domain containing
MET MET proto-oncogene, receptor tyrosine kinase
NOTCH2 notch 2
NREP neuronal regeneration related protein
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
PALMD palmdelphin
PERP PERP, TP53 apoptosis effector
PODXL podocalyxin-like
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SVIL supervillin
SYT1 synaptotagmin I
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TES testin LIM domain protein
TMPO thymopoietin
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
WFDC2 WAP four-disulfide core domain 2