BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP8L A kinase (PRKA) anchor protein 8-like
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
C8ORF4 chromosome 8 open reading frame 4
CARS cysteinyl-tRNA synthetase
CCND2 cyclin D2
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP4 dual specificity phosphatase 4
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GARS glycyl-tRNA synthetase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
IL6R interleukin 6 receptor
KIAA0020 KIAA0020
KLF10 Kruppel-like factor 10
KLK10 kallikrein-related peptidase 10
KYNU kynureninase
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LY75 lymphocyte antigen 75
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NUPL1 nucleoporin like 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDPK1 3-phosphoinositide dependent protein kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCYL3 SCY1-like 3 (S. cerevisiae)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A6 solute carrier family 16, member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNX11 sorting nexin 11
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCPKMT valosin containing protein lysine (K) methyltransferase
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase
ZNF140 zinc finger protein 140
ZNF468 zinc finger protein 468

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
APLP2 amyloid beta (A4) precursor-like protein 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BCHE butyrylcholinesterase
CALD1 caldesmon 1
CAV2 caveolin 2
CD53 CD53 molecule
CD58 CD58 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL1A2 collagen, type I, alpha 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DHRS1 dehydrogenase/reductase (SDR family) member 1
DPYD dihydropyrimidine dehydrogenase
DSTN destrin (actin depolymerizing factor)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPN2 epsin 2
FXYD5 FXYD domain containing ion transport regulator 5
GRK5 G protein-coupled receptor kinase 5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
IQGAP1 IQ motif containing GTPase activating protein 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMP1 lysosomal-associated membrane protein 1
LAPTM5 lysosomal protein transmembrane 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEIS2 Meis homeobox 2
MOB1A MOB kinase activator 1A
NLRP2 NLR family, pyrin domain containing 2
PEG10 paternally expressed 10
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS10 regulator of G-protein signaling 10
SDC2 syndecan 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTBN1 spectrin, beta, non-erythrocytic 1
STMN1 stathmin 1
TCF4 transcription factor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF589 zinc finger protein 589