BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

230 genes differentially expressed following the BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ATMIN ATM interactor
BIN1 bridging integrator 1
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
C1ORF116 chromosome 1 open reading frame 116
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHERP calcium homeostasis endoplasmic reticulum protein
CLTB clathrin, light chain B
CLU clusterin
COTL1 coactosin-like F-actin binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ELF4 E74-like factor 4 (ets domain transcription factor)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FSCN1 fascin actin-bundling protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KYNU kynureninase
LIPG lipase, endothelial
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAGEA3 melanoma antigen family A3
MAP1B microtubule-associated protein 1B
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MT1X metallothionein 1X
NCAM1 neural cell adhesion molecule 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOSIP nitric oxide synthase interacting protein
NOTCH1 notch 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPL1 nucleoporin like 1
NXF1 nuclear RNA export factor 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTRF polymerase I and transcript release factor
RHOF ras homolog family member F (in filopodia)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC35F2 solute carrier family 35, member F2
SMAD3 SMAD family member 3
SMOX spermine oxidase
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
STOM stomatin
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBX3 T-box 3
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TOMM34 translocase of outer mitochondrial membrane 34
TRIB1 tribbles pseudokinase 1
TUBA4A tubulin, alpha 4a
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCL vinculin
ZYX zyxin

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ARMCX2 armadillo repeat containing, X-linked 2
ARMT1 acidic residue methyltransferase 1
ATAD2 ATPase family, AAA domain containing 2
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CA12 carbonic anhydrase XII
CANX calnexin
CAV2 caveolin 2
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPU centromere protein U
CFB complement factor B
CHN1 chimerin 1
CLDN3 claudin 3
CNN3 calponin 3, acidic
COG5 component of oligomeric golgi complex 5
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DDR1 discoidin domain receptor tyrosine kinase 1
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNALI1 dynein, axonemal, light intermediate chain 1
DPP4 dipeptidyl-peptidase 4
ECT2 epithelial cell transforming 2
EIF4B eukaryotic translation initiation factor 4B
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FABP7 fatty acid binding protein 7, brain
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
FZD6 frizzled class receptor 6
GALC galactosylceramidase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GPC4 glypican 4
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTA1 glutathione S-transferase alpha 1
HIST1H4C histone cluster 1, H4c
HNMT histamine N-methyltransferase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
IRX5 iroquois homeobox 5
IVNS1ABP influenza virus NS1A binding protein
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN1A1 mannosidase, alpha, class 1A, member 1
MANSC1 MANSC domain containing 1
MCAM melanoma cell adhesion molecule
MDFIC MyoD family inhibitor domain containing
MPC2 mitochondrial pyruvate carrier 2
MUC1 mucin 1, cell surface associated
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNT nicotinamide nucleotide transhydrogenase
NUCB2 nucleobindin 2
PAM peptidylglycine alpha-amidating monooxygenase
PBK PDZ binding kinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
RAD51AP1 RAD51 associated protein 1
RBBP8 retinoblastoma binding protein 8
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC4 replication factor C (activator 1) 4, 37kDa
RHOBTB3 Rho-related BTB domain containing 3
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNASE4 ribonuclease, RNase A family, 4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCP2 sterol carrier protein 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
STX7 syntaxin 7
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM14A transmembrane protein 14A
TMEM251 transmembrane protein 251
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TSPYL5 TSPY-like 5
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon