BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BCAS2 breast carcinoma amplified sequence 2
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CCNE2 cyclin E2
CCNL1 cyclin L1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CIRBP cold inducible RNA binding protein
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
CREM cAMP responsive element modulator
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CTSL cathepsin L
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
FAM13B family with sequence similarity 13, member B
FAM53C family with sequence similarity 53, member C
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FST follistatin
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NET1 neuroepithelial cell transforming 1
NEU1 sialidase 1 (lysosomal sialidase)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
NXF1 nuclear RNA export factor 1
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOB1 transducer of ERBB2, 1
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UBE2A ubiquitin-conjugating enzyme E2A
UPP1 uridine phosphorylase 1
VIM vimentin
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADAM10 ADAM metallopeptidase domain 10
AK4 adenylate kinase 4
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AURKA aurora kinase A
BMP4 bone morphogenetic protein 4
CA12 carbonic anhydrase XII
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCNA2 cyclin A2
CLCA4 chloride channel accessory 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFHD1 EF-hand domain family, member D1
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
HMGB3 high mobility group box 3
KIF20A kinesin family member 20A
LMNB1 lamin B1
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MUC4 mucin 4, cell surface associated
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
PDE4A phosphodiesterase 4A, cAMP-specific
RAD21 RAD21 homolog (S. pombe)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TCL1A T-cell leukemia/lymphoma 1A
TM9SF2 transmembrane 9 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TSPAN12 tetraspanin 12
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)