BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMOTL2 angiomotin like 2
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNL1 cyclin L1
CD163 CD163 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM53C family with sequence similarity 53, member C
FEM1C fem-1 homolog c (C. elegans)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1X metallothionein 1X
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PCP4 Purkinje cell protein 4
PDLIM3 PDZ and LIM domain 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPL periplakin
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SCYL3 SCY1-like 3 (S. cerevisiae)
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SNX11 sorting nexin 11
SOCS3 suppressor of cytokine signaling 3
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TDO2 tryptophan 2,3-dioxygenase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TSPAN5 tetraspanin 5
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF274 zinc finger protein 274
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADRB2 adrenoceptor beta 2, surface
B3GNT1
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
COX11 COX11 cytochrome c oxidase copper chaperone
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL5 chemokine (C-X-C motif) ligand 5
DSTN destrin (actin depolymerizing factor)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFI44L interferon-induced protein 44-like
LASP1 LIM and SH3 protein 1
OLFM1 olfactomedin 1
PCNA proliferating cell nuclear antigen
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
SCP2 sterol carrier protein 2
SEC23A Sec23 homolog A (S. cerevisiae)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPP1 secreted phosphoprotein 1
SRSF1 serine/arginine-rich splicing factor 1
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TMEM230 transmembrane protein 230
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TXN thioredoxin
WRB tryptophan rich basic protein