BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

280 genes differentially expressed following the BRD-K53932786_2-Dichloromethyl-4-ethylsulfanyl-6-phenyl-[1,3,5]triazine MLS-0208612.0001_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
ARC activity-regulated cytoskeleton-associated protein
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C4BPA complement component 4 binding protein, alpha
C6ORF48 chromosome 6 open reading frame 48
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CCNG2 cyclin G2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL14A1 collagen, type XIV, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DBT dihydrolipoamide branched chain transacylase E2
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM117A family with sequence similarity 117, member A
FAM46C family with sequence similarity 46, member C
FCMR Fc fragment of IgM receptor
FHL2 four and a half LIM domains 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GNAS GNAS complex locus
GPM6B glycoprotein M6B
HAL histidine ammonia-lyase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IL6 interleukin 6
IL6R interleukin 6 receptor
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
LIPG lipase, endothelial
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LUM lumican
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MIR22HG MIR22 host gene
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NKX3-1 NK3 homeobox 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SOCS3 suppressor of cytokine signaling 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOB1 transducer of ERBB2, 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF165 zinc finger protein 165
ZNF331 zinc finger protein 331
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADCY9 adenylate cyclase 9
AKR1C3 aldo-keto reductase family 1, member C3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANPEP alanyl (membrane) aminopeptidase
APP amyloid beta (A4) precursor protein
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
AUTS2 autism susceptibility candidate 2
B3GNT1
CA12 carbonic anhydrase XII
CCL5 chemokine (C-C motif) ligand 5
CD46 CD46 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CLCA4 chloride channel accessory 4
COL3A1 collagen, type III, alpha 1
CSRP2 cysteine and glycine-rich protein 2
DSCC1 DNA replication and sister chromatid cohesion 1
EMP2 epithelial membrane protein 2
FGFR3 fibroblast growth factor receptor 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIF20A kinesin family member 20A
LAMP1 lysosomal-associated membrane protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LMNB2 lamin B2
LOXL2 lysyl oxidase-like 2
LYZ lysozyme
MDFIC MyoD family inhibitor domain containing
MEX3D mex-3 RNA binding family member D
MKL2 MKL/myocardin-like 2
MRPS28 mitochondrial ribosomal protein S28
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
NRP1 neuropilin 1
OLFML2A olfactomedin-like 2A
PARP1 poly (ADP-ribose) polymerase 1
PDE10A phosphodiesterase 10A
PDIA3 protein disulfide isomerase family A, member 3
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
PON2 paraoxonase 2
PSCA prostate stem cell antigen
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCARB2 scavenger receptor class B, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRSF1 serine/arginine-rich splicing factor 1
TFDP1 transcription factor Dp-1
TM9SF2 transmembrane 9 superfamily member 2
TMEM30A transmembrane protein 30A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN12 tetraspanin 12
UXS1 UDP-glucuronate decarboxylase 1
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1
VWF von Willebrand factor
ZMYM3 zinc finger, MYM-type 3